PMID- 36495691
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230314
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 444
DP  - 2023 Jan 15
TI  - Unaltered T cell responses to common antigens in individuals with Parkinson's 
      disease.
PG  - 120510
LID - S0022-510X(22)00372-0 [pii]
LID - 10.1016/j.jns.2022.120510 [doi]
AB  - BACKGROUND AND OBJECTIVES: Parkinson's disease (PD) is associated with a 
      heightened inflammatory state, including activated T cells. However, it is 
      unclear whether these PD T cell responses are antigen specific or more indicative 
      of generalized hyperresponsiveness. Our objective was to measure and compare 
      antigen-specific T cell responses directed towards antigens derived from commonly 
      encountered human pathogens/vaccines in patients with PD and age-matched healthy 
      controls (HC). METHODS: Peripheral blood mononuclear cells (PBMCs) from 20 PD 
      patients and 19 age-matched HCs were screened. Antigen specific T cell responses 
      were measured by flow cytometry using a combination of the activation induced 
      marker (AIM) assay and intracellular cytokine staining. RESULTS: Here we show 
      that both PD patients and HCs show similar T cell activation levels to several 
      antigens derived from commonly encountered human pathogens/vaccines in the 
      general population. Similarly, we also observed no difference between HC and PD 
      in the levels of CD4 and CD8 T cell derived cytokines produced in response to any 
      of the common antigens tested. These antigens encompassed both viral 
      (coronavirus, rhinovirus, respiratory syncytial virus, influenza, 
      cytomegalovirus) and bacterial (pertussis, tetanus) targets. CONCLUSIONS: These 
      results suggest the T cell dysfunction observed in PD may not extend itself to 
      abnormal responses to commonly encountered or vaccine-target antigens. Our study 
      supports the notion that the targets of inflammatory T cell responses in PD may 
      be more directed towards autoantigens like alpha-synuclein (alpha-syn) rather than common 
      foreign antigens.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Williams, Gregory P
AU  - Williams GP
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA; Aligning Science Across Parkinson's (ASAP) 
      Collaborative Research Network, Chevy Chase, MD, USA.
FAU - Muskat, Kaylin
AU  - Muskat K
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA.
FAU - Frazier, April
AU  - Frazier A
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA; Aligning Science Across Parkinson's (ASAP) 
      Collaborative Research Network, Chevy Chase, MD, USA.
FAU - Xu, Yaqian
AU  - Xu Y
AD  - Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy 
      Chase, MD, USA; Department of Neurology, Columbia University Irving Medical 
      Center, New York, NY 10032, USA.
FAU - Mateus, Jose
AU  - Mateus J
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA.
FAU - Grifoni, Alba
AU  - Grifoni A
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA.
FAU - da Silva Antunes, Ricardo
AU  - da Silva Antunes R
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA.
FAU - Weiskopf, Daniela
AU  - Weiskopf D
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA.
FAU - Amara, Amy W
AU  - Amara AW
AD  - Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy 
      Chase, MD, USA; Department of Neurology, University of Alabama at Birmingham, 
      Birmingham, AL 35233, USA.
FAU - Standaert, David G
AU  - Standaert DG
AD  - Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy 
      Chase, MD, USA; Department of Neurology, University of Alabama at Birmingham, 
      Birmingham, AL 35233, USA.
FAU - Goldman, Jennifer G
AU  - Goldman JG
AD  - Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine, 
      Chicago, IL 60611, USA.
FAU - Litvan, Irene
AU  - Litvan I
AD  - Department of Neuroscience, University of California San Diego, La Jolla, CA 
      92093, USA.
FAU - Alcalay, Roy N
AU  - Alcalay RN
AD  - Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, 
      Israel.
FAU - Sulzer, David
AU  - Sulzer D
AD  - Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy 
      Chase, MD, USA; Department of Psychiatry, Columbia University Irving Medical 
      Center, New York State Psychiatric Institute, New York, NY 10032, USA; 
      Departments of Psychiatry and Pharmacology, Columbia University; New York State 
      Psychiatric Institute, New York, NY 10032, USA.
FAU - Lindestam Arlehamn, Cecilia S
AU  - Lindestam Arlehamn CS
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA; Aligning Science Across Parkinson's (ASAP) 
      Collaborative Research Network, Chevy Chase, MD, USA. Electronic address: 
      cecilia@lji.org.
FAU - Sette, Alessandro
AU  - Sette A
AD  - Center for Infectious Disease and Vaccine Research, La Jolla Institute for 
      Immunology, La Jolla, CA 92037, USA; Aligning Science Across Parkinson's (ASAP) 
      Collaborative Research Network, Chevy Chase, MD, USA; Department of Medicine, 
      University of California San Diego, La Jolla, CA 92093, USA. Electronic address: 
      alex@lji.org.
LA  - eng
GR  - P50 NS108675/NS/NINDS NIH HHS/United States
GR  - T32 AI125179/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20221125
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Cytokines)
RN  - 0 (Vaccines)
SB  - IM
MH  - Humans
MH  - T-Lymphocytes
MH  - *Parkinson Disease
MH  - Leukocytes, Mononuclear
MH  - Cytokines
MH  - *Vaccines
PMC - PMC9950758
MID - NIHMS1858802
OTO - NOTNLM
OT  - Bacterial immunity
OT  - Immune system
OT  - Inflammation
OT  - Neurodegeneration
OT  - Neuroimmunology
OT  - Parkinson's disease
OT  - T cells
OT  - Viral immunity
EDAT- 2022/12/11 06:00
MHDA- 2023/01/24 06:00
PMCR- 2023/02/24
CRDT- 2022/12/10 18:21
PHST- 2022/05/02 00:00 [received]
PHST- 2022/11/15 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/11 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
PHST- 2022/12/10 18:21 [entrez]
PHST- 2023/02/24 00:00 [pmc-release]
AID - S0022-510X(22)00372-0 [pii]
AID - 10.1016/j.jns.2022.120510 [doi]
PST - ppublish
SO  - J Neurol Sci. 2023 Jan 15;444:120510. doi: 10.1016/j.jns.2022.120510. Epub 2022 
      Nov 25.