PMID- 36495928
OWN - NLM
STAT- MEDLINE
DCOM- 20230201
LR  - 20230202
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 539
DP  - 2023 Jan 15
TI  - Concentration of hs-Troponin in small cohort of transgender patients.
PG  - 66-69
LID - S0009-8981(22)01405-X [pii]
LID - 10.1016/j.cca.2022.12.003 [doi]
AB  - INTRODUCTION: Sex-differences in high sensitivity troponin (hs-Tn) concentrations 
      are well established. There is, however, limited data to guide interpretation of 
      hs-Tn in transgender patients, particularly those receiving gender-affirming 
      hormone therapy. Our purpose was to evaluate troponin testing in transgender 
      patients. METHODS: Transgender adults attending a routine clinic visit provided 
      demographic data, medical history, and venous blood samples. Patients with 
      congestive heart failure or chronic kidney disease were excluded. hs-Tn was 
      measured using the Architect Stat High Sensitivity Troponin-I (Abbott), Access 2 
      hsTnI (Beckman Coulter), and Elecsys Troponin T Gen 5 STAT (Roche) assays. hs-Tn 
      below the limit of detection (LOD) is reported as the lower limit of detection 
      (LLOD) RESULTS: Of 63 subjects, 76 % were transgender women. We found no 
      significant difference in median hs-Tn concentrations or proportions of 
      hs-Tn > LOD. CONCLUSION: In this cohort of stable transgender patients without 
      CHF or CKD, we did not observe differences in hs-Tn concentrations between 
      transgender women and transgender men. Meaningful conclusions are limited owing 
      to inadequate sample size and population differences. Further research on 
      hs-troponin concentrations in this underrepresented, vulnerable population is 
      needed.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Boone, Stephen
AU  - Boone S
AD  - Emergency Medicine, Baylor College of Medicine, Ben Taub General Hospital, 
      Department of Emergency Medicine, 1504 Taub Loop, Houston, TX 77021, USA. 
      Electronic address: Stephen.boone@bcm.edu.
FAU - Peacock, W Frank
AU  - Peacock WF
AD  - Emergency Medicine, Baylor College of Medicine, Ben Taub General Hospital, 
      Department of Emergency Medicine, 1504 Taub Loop, Houston, TX 77021, USA.
FAU - Wu, Alan H B
AU  - Wu AHB
AD  - Laboratory Medicine, Chief, Clinical Chemistry Laboratory, SFGH, Chief, Clinical 
      Pharmacogenomics Laboratory, UCSF. Zuckerberg San Francisco General Hospital, 
      1001 Potrero Avenue, Room 2M27, San Francisco, CA 94110, USA.
FAU - Jaffe, Allan
AU  - Jaffe A
AD  - Cardiology, Professor of Laboratory Medicine and Pathology, Mayo Clinic, Gonda 
      Building 5th Floor, 200 First St. S.W., Rochester, MN 55905, USA.
FAU - Christenson, Robert H
AU  - Christenson RH
AD  - Professor of Pathology, Professor of Medical and Research Technology. University 
      of Maryland School of Medicine, Medical Director of Core Laboratories, Medical 
      Director of Point of Care Services, University of Maryland Medical Center, 
      College Park, MD, USA.
FAU - Ettner, Frederic M
AU  - Ettner FM
AD  - Family Medicine, Department of Family Medicine, University of Chicago Pritzker 
      School of Medicine, 7126 N. Lincoln Avenue, Lincolnwood, IL 60712, USA.
FAU - Dadkhah, Shahriar
AU  - Dadkhah S
AD  - Clinical Professor of Medicine, University of Illinois at Chicago, 7126 N. 
      Lincoln Ave, Lincolnwood, IL 60712, USA.
LA  - eng
PT  - Journal Article
DEP - 20221208
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Troponin I)
RN  - 0 (Troponin T)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Male
MH  - Adult
MH  - Humans
MH  - Female
MH  - *Transgender Persons
MH  - Troponin I
MH  - Troponin T
MH  - Limit of Detection
MH  - Blood Coagulation Tests
MH  - Biomarkers
OTO - NOTNLM
OT  - Cardiac biomarkers
OT  - High-sensitivity troponin
OT  - Transgender
OT  - Troponin
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/11 06:00
MHDA- 2023/02/02 06:00
CRDT- 2022/12/10 19:22
PHST- 2022/09/12 00:00 [received]
PHST- 2022/11/30 00:00 [revised]
PHST- 2022/12/02 00:00 [accepted]
PHST- 2022/12/11 06:00 [pubmed]
PHST- 2023/02/02 06:00 [medline]
PHST- 2022/12/10 19:22 [entrez]
AID - S0009-8981(22)01405-X [pii]
AID - 10.1016/j.cca.2022.12.003 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2023 Jan 15;539:66-69. doi: 10.1016/j.cca.2022.12.003. Epub 2022 
      Dec 8.