PMID- 36496058
OWN - NLM
STAT- MEDLINE
DCOM- 20230119
LR  - 20230119
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 174
DP  - 2023 Jan
TI  - Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling 
      by enhancing peroxiredoxin-1 expression in GES-1 cells.
PG  - 105937
LID - S0882-4010(22)00550-2 [pii]
LID - 10.1016/j.micpath.2022.105937 [doi]
AB  - Helicobacter pylori (H. pylori), a gram-negative bacterial microbiological 
      carcinogen, has been identified as the leading jeopardy feature for developing 
      human gastric cancer (GC). As a result, inhibiting H. pylori growth has been 
      identified as an effective and critical technique for preventing GC development. 
      In this study, geraniol inhibits H. pylori-induced gastric carcinogen signalling 
      in human gastric epithelial cells (GES-1). Geraniol prevents cytotoxicity, ROS 
      and apoptosis in H. pylori-induced GES-1 cells. Furthermore, geraniol protects 
      against H. -induced antioxidant depletion caused by malondialdehyde, damage of 
      reactive DNA and nuclear fragmentation. Geraniol significantly reduced the 
      expression of phosphorylated mitogen activated protein kinases (MAPKs) proteins 
      such as p38 MAPK, extracellular signal-regulated kinase-1 (ERK1), c-Jun 
      N-terminal kinase (c-JNK), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 
      (IL-6), and cyclooxygenase-2 (COX-2) in GES-1 infected with H. pylori. 
      Furthermore, geraniol increased the antioxidant protein peroxiredoxin-1 (Prdx-1) 
      in H. pylori-infected cells. Geraniol thus protects H. pylori-concomitant 
      infection, and its resistance may be a possible method in preventing gastric 
      cancer caused by H. pylori.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Zhuang, Kun
AU  - Zhuang K
AD  - Department of Gastroenterology, Xi'an Central Hospital, Xi'an, 710003, China. 
      Electronic address: zhuanger6695@sina.com.
FAU - Tang, Hailing
AU  - Tang H
AD  - Department of Gastroenterology, Xi'an Central Hospital, Xi'an, 710003, China.
FAU - Guo, Hanqing
AU  - Guo H
AD  - Department of Gastroenterology, Xi'an Central Hospital, Xi'an, 710003, China.
FAU - Yuan, Shanshan
AU  - Yuan S
AD  - Department of Gastroenterology, Xi'an Central Hospital, Xi'an, 710003, China.
LA  - eng
PT  - Journal Article
DEP - 20221208
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Antioxidants)
RN  - 0 (Carcinogens)
RN  - L837108USY (geraniol)
RN  - EC 1.11.1.15 (PRDX1 protein, human)
SB  - IM
MH  - Humans
MH  - Antioxidants/pharmacology/metabolism
MH  - Carcinogens/metabolism/pharmacology
MH  - Epithelial Cells
MH  - Gastric Mucosa/pathology
MH  - *Helicobacter Infections/microbiology
MH  - *Helicobacter pylori
MH  - *Stomach Neoplasms/pathology
OTO - NOTNLM
OT  - GES-1 cell line
OT  - Gastric cancer
OT  - Geraniol
OT  - H. pylori
OT  - Oxidative DNA damage
COIS- Declaration of competing interest None.
EDAT- 2022/12/11 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/10 19:24
PHST- 2022/11/01 00:00 [received]
PHST- 2022/11/30 00:00 [revised]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2022/12/11 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/10 19:24 [entrez]
AID - S0882-4010(22)00550-2 [pii]
AID - 10.1016/j.micpath.2022.105937 [doi]
PST - ppublish
SO  - Microb Pathog. 2023 Jan;174:105937. doi: 10.1016/j.micpath.2022.105937. Epub 2022 
      Dec 8.