PMID- 36497472
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221221
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 23
DP  - 2022 Dec 4
TI  - The Use of Mechanical Bowel Preparation and Oral Antibiotic Prophylaxis in 
      Elective Colorectal Surgery: A Call for Change in Practice.
LID - 10.3390/cancers14235990 [doi]
LID - 5990
AB  - Elective colorectal surgery is associated with one of the highest rates of 
      surgical site infections (SSIs), which result in prolonged length of stay, 
      morbidity, and mortality for these patients and have a significant financial 
      burden to healthcare systems. In an effort to reduce the frequency of SSI rates 
      associated with colorectal surgery, the 2018 World Health Organisation (WHO) 
      guidelines recommend the routine use of mechanical bowel preparation (MBP) and 
      oral antibiotic prophylaxis (OAP) in adult patients undergoing elective 
      colorectal surgery. However, this recommendation remains a topic of debate 
      internationally. The National Institute of Clinical Excellence (NICE) guidelines, 
      last revised in 2019, recommend against the routine use of MBP and do not address 
      the issue of OAP. In this communication, we reviewed the current guidelines and 
      examined the most recent evidence from randomised-control trials (RCTs) and 
      meta-analyses on the effect of MBP and OAP on SSI rates since the 2019 NICE 
      guideline review. This recent evidence clearly demonstrated an SSI-risk-reduction 
      benefit with the additional use of OAP and the combination of MBP and OAP in this 
      group of patients, and we therefore highlight the need for change of the current 
      NICE guidelines.
FAU - Petrou, Nikoletta A
AU  - Petrou NA
AUID- ORCID: 0000-0001-6295-2451
AD  - Department of Surgery, The Royal Marsden Hospital, London SW3 6JJ, UK.
FAU - Kontovounisios, Christos
AU  - Kontovounisios C
AUID- ORCID: 0000-0002-1828-1395
AD  - Department of Surgery, The Royal Marsden Hospital, London SW3 6JJ, UK.
AD  - Department of Surgery and Cancer, Imperial College London, London SW7 2BX, UK.
AD  - Department of General Surgery, Chelsea and Westminster Hospital, London SW10 9NH, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20221204
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC9740331
OTO - NOTNLM
OT  - colorectal surgery
OT  - mechanical bowel preparation
OT  - oral antibiotic prophylaxis
OT  - surgical site infections
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/12 06:01
PMCR- 2022/12/04
CRDT- 2022/12/11 01:05
PHST- 2022/10/18 00:00 [received]
PHST- 2022/12/01 00:00 [revised]
PHST- 2022/12/02 00:00 [accepted]
PHST- 2022/12/11 01:05 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/12 06:01 [medline]
PHST- 2022/12/04 00:00 [pmc-release]
AID - cancers14235990 [pii]
AID - cancers-14-05990 [pii]
AID - 10.3390/cancers14235990 [doi]
PST - epublish
SO  - Cancers (Basel). 2022 Dec 4;14(23):5990. doi: 10.3390/cancers14235990.