PMID- 36498595
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221221
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 23
DP  - 2022 Nov 28
TI  - The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant 
      Protein-1: A Systematic Review and Meta-Analysis.
LID - 10.3390/jcm11237021 [doi]
LID - 7021
AB  - Background: MCP-1 (monocyte chemoattractant protein) plays an important role in 
      early phases of atherogenesis as well as in plaque destabilization, which causes 
      cardiovascular events to play an important role in low-grade inflammation. 
      Obesity, particularly extreme obesity, is a pivotal risk factor for 
      atherosclerosis and many other diseases. In the early stages, bariatric surgery 
      might stop or slow atherogenesis by suppressing inflammation, but also in later 
      stages, preventing plaque destabilization. The aim of this meta-analysis was to 
      provide an answer as to whether bariatric surgery has a significant effect on 
      circulating MCP-1 level or not. Methods: A systematic literature search in 
      PubMed, Scopus, Embase, and Web of Science was performed from inception to 1 
      January 2022. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) 
      V2 software. In order to heterogeneity compensation of studies in terms of study 
      design and treatment duration, the characteristics of the studied populations 
      random-effects model and the generic inverse variance weighting method were used. 
      To investigate the relationship with the estimated effect size, a random-effect 
      meta-regression model was used. To assess the exitance of publication bias in the 
      meta-analysis, the funnel plot, Begg's rank correlation, and Egger's weighted 
      regression tests were used. Results: Meta-analysis of 25 studies with 927 
      subjects included demonstrated a significant decrease of MCP-1 concentration 
      after bariatric surgery. The data of meta-regression did not indicate any 
      association between the alterations in body mass index (BMI) and absolute 
      difference in MCP-1 levels, but a linear relationship between the changes in 
      MCP-1 and length of follow-up was proven. Conclusions: Bariatric surgery 
      significantly decreases MCP-1 concentration, but there was no association between 
      the changes in BMI and absolute difference in MCP-1 levels before and after the 
      surgery.
FAU - Jamialahmadi, Tannaz
AU  - Jamialahmadi T
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Surgical Oncology Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Abbasifard, Mitra
AU  - Abbasifard M
AD  - Immunology of Infectious Diseases Research Center, Research Institute of Basic 
      Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
AD  - Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, 
      Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
FAU - Reiner, Zeljko
AU  - Reiner Z
AD  - Department of Internal Medicine, University Hospital Center Zagreb, 10000 Zagreb, 
      Croatia.
FAU - Kesharwani, Prashant
AU  - Kesharwani P
AUID- ORCID: 0000-0002-0890-769X
AD  - Department of Pharmaceutics, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India.
AD  - Center for Transdisciplinary Research, Department of Pharmacology, Saveetha 
      Dental College, Saveetha Institute of Medical and Technical Science, Chennai 
      602105, India.
FAU - Sahebkar, Amirhossein
AU  - Sahebkar A
AUID- ORCID: 0000-0002-8656-1444
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Department of Biotechnology, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20221128
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9738353
OTO - NOTNLM
OT  - atherosclerosis
OT  - bariatric surgery
OT  - cardiovascular disease
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/12 06:01
PMCR- 2022/11/28
CRDT- 2022/12/11 01:14
PHST- 2022/10/06 00:00 [received]
PHST- 2022/11/18 00:00 [revised]
PHST- 2022/11/24 00:00 [accepted]
PHST- 2022/12/11 01:14 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/12 06:01 [medline]
PHST- 2022/11/28 00:00 [pmc-release]
AID - jcm11237021 [pii]
AID - jcm-11-07021 [pii]
AID - 10.3390/jcm11237021 [doi]
PST - epublish
SO  - J Clin Med. 2022 Nov 28;11(23):7021. doi: 10.3390/jcm11237021.