PMID- 36498673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 23
DP  - 2022 Nov 30
TI  - MCP1 Could Mediate FGF23 and Omega 6/Omega 3 Correlation Inversion in CKD.
LID - 10.3390/jcm11237099 [doi]
LID - 7099
AB  - Fibroblast growth factor 23 (FGF23) concentrations rise after the early stages of 
      chronic kidney disease (CKD). FGF23 is involved in inflammatory reactions closely 
      associated with an incremented risk of cardiovascular disease (CVD). There is 
      growing evidence that omega-6 (n-6) and n-3 polyunsaturated fatty acids (PUFA) 
      can modulate inflammation through several mediators producing an opposite effect 
      on cardiovascular (CV) risks. In this study, we explore whether there is any 
      correlation between PUFA, FGF23, and inflammation in CKD patients. We evaluated, 
      cross-sectionally, 56 patients at different stages of CKD. Monocyte 
      chemoattractant protein 1 (MCP1), and intact and c-terminal FGF23 (iFGF23, 
      cFGF23) were quantified by the ELISA, and the fatty acids (FA) profile was 
      analyzed by gas chromatography. Concurrently with an eGFR decrease (p < 0.01) and 
      an MCP1 increase (p = 0.031), we observed an inversion of the correlation between 
      FGF23 and the n-6/n-3 ratio. This last correlation was inversed in CKD stage 3 
      (r2 (-) 0.502 p = 0.029) and direct in stage 5 (r2 0.657 p = 0.020). The increase 
      in MCP1 seems to trigger events in the inversion of the correlation between FGF23 
      and the n-6/n-3 PUFA ratio. This result strongly encourages future studies on 
      basal pathways, on possible pharmacological interventions, and on managing kidney 
      transplant patients treated with immunosuppressive therapy.
FAU - Mattinzoli, Deborah
AU  - Mattinzoli D
AUID- ORCID: 0000-0003-0478-022X
AD  - Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, 20122 Milan, Italy.
FAU - Turolo, Stefano
AU  - Turolo S
AUID- ORCID: 0000-0002-9178-0713
AD  - Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Alfieri, Carlo Maria
AU  - Alfieri CM
AD  - Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS 
      Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, University of Milan, 20122 
      Milan, Italy.
FAU - Ikehata, Masami
AU  - Ikehata M
AUID- ORCID: 0000-0001-9835-9991
AD  - Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, 20122 Milan, Italy.
FAU - Caldiroli, Lara
AU  - Caldiroli L
AD  - Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS 
      Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Armelloni, Silvia
AU  - Armelloni S
AUID- ORCID: 0000-0001-6431-2642
AD  - Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, 20122 Milan, Italy.
FAU - Montini, Giovanni
AU  - Montini G
AUID- ORCID: 0000-0002-7350-4475
AD  - Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, University of Milan, 20122 
      Milan, Italy.
FAU - Agostoni, Carlo
AU  - Agostoni C
AD  - Department of Clinical Sciences and Community Health, University of Milan, 20122 
      Milan, Italy.
AD  - Pediatric Intermediate Care Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore 
      Policlinico, 20122 Milan, Italy.
FAU - Messa, Piergiorgio
AU  - Messa P
AD  - Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS 
      Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, University of Milan, 20122 
      Milan, Italy.
FAU - Vettoretti, Simone
AU  - Vettoretti S
AUID- ORCID: 0000-0002-1040-4952
AD  - Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS 
      Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Castellano, Giuseppe
AU  - Castellano G
AD  - Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS 
      Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, University of Milan, 20122 
      Milan, Italy.
LA  - eng
GR  - Current research/Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico/
PT  - Journal Article
DEP - 20221130
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9739884
OTO - NOTNLM
OT  - CKD
OT  - FGF23
OT  - fatty acids
OT  - inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/12 06:01
PMCR- 2022/11/30
CRDT- 2022/12/11 01:14
PHST- 2022/10/25 00:00 [received]
PHST- 2022/11/23 00:00 [revised]
PHST- 2022/11/24 00:00 [accepted]
PHST- 2022/12/11 01:14 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/12 06:01 [medline]
PHST- 2022/11/30 00:00 [pmc-release]
AID - jcm11237099 [pii]
AID - jcm-11-07099 [pii]
AID - 10.3390/jcm11237099 [doi]
PST - epublish
SO  - J Clin Med. 2022 Nov 30;11(23):7099. doi: 10.3390/jcm11237099.