PMID- 36499525
OWN - NLM
STAT- MEDLINE
DCOM- 20221219
LR  - 20221221
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 23
DP  - 2022 Dec 2
TI  - Are There Differences in Inflammatory and Fibrotic Pathways between IPAF, 
      CTD-ILDs, and IIPs? A Single-Center Pilot Study.
LID - 10.3390/ijms232315205 [doi]
LID - 15205
AB  - In this pilot study, we aim to determine differences in pathogenetic pathways 
      between interstitial pneumonia with autoimmune features (IPAF), 
      connective-tissue-disease-associated interstitial lung diseases (CTD-ILDs), and 
      idiopathic interstitial pneumonias (IIPs). Forty participants were recruited: 9 
      with IPAF, 15 with CTD-ILDs, and 16 with IIPs. Concentration of transforming 
      growth factor beta (TGF-beta1), surfactant proteins A and D (SP-A, SP-D), 
      interleukin 8 (IL-8), and chemokine 1 (CXCL1) were assessed with ELISA assay in 
      bronchoalveolar lavage (BAL) fluid. We revealed that IL-8 and TGF-beta1 
      concentrations were significantly lower in the IPAF group than in the CTD-ILD 
      group (p = 0.008 and p = 0.019, respectively), but similar to the concentrations 
      in the IIP group. There were significant correlations of IL-8 (rs = 0.46; p = 
      0.003) and CXCL1 (rs = 0.52; p = 0.001) and BAL total cell count (TCC). A 
      multivariate regression model revealed that IL-8 (beta = 0.32; p = 0.037) and CXCL1 
      (beta = 0.45; p = 0.004) are significant predictors of BAL TCC. We revealed that 
      IL-8 and TGF-beta1 BAL concentrations vary in patients with different ILDs and found 
      that IL-8 is a predictor of BAL TCC in IPAF. However, this needs to be confirmed 
      in a multicenter cooperative study (ClinicalTrials.gov Identifier: NCT03870828).
FAU - Rzepka-Wrona, Patrycja
AU  - Rzepka-Wrona P
AD  - Department of Pneumonology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-055 Katowice, Poland.
FAU - Skoczynski, Szymon
AU  - Skoczynski S
AUID- ORCID: 0000-0003-1796-7659
AD  - Department of Pneumonology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-055 Katowice, Poland.
FAU - Barczyk, Adam
AU  - Barczyk A
AUID- ORCID: 0000-0002-6567-9208
AD  - Department of Pneumonology, Faculty of Medical Sciences in Katowice, Medical 
      University of Silesia, 40-055 Katowice, Poland.
LA  - eng
SI  - ClinicalTrials.gov/NCT03870828
GR  - PCN-1-066/K/2/K/Medical University of Silesia/
PT  - Clinical Study
PT  - Journal Article
DEP - 20221202
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Interleukin-8)
RN  - 0 (Pulmonary Surfactant-Associated Protein D)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Humans
MH  - Fibrosis
MH  - *Idiopathic Interstitial Pneumonias/complications
MH  - Interleukin-8
MH  - *Lung Diseases, Interstitial/pathology
MH  - Pilot Projects
MH  - Pulmonary Surfactant-Associated Protein D
MH  - Transforming Growth Factor beta1
PMC - PMC9738037
OTO - NOTNLM
OT  - CTD-ILDs
OT  - IIPs
OT  - IPAF
OT  - bronchoalveolar lavage
OT  - interstitial lung disease
OT  - interstitial pneumonia
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/12/02
CRDT- 2022/12/11 01:20
PHST- 2022/10/27 00:00 [received]
PHST- 2022/11/26 00:00 [revised]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/11 01:20 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/12/02 00:00 [pmc-release]
AID - ijms232315205 [pii]
AID - ijms-23-15205 [pii]
AID - 10.3390/ijms232315205 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Dec 2;23(23):15205. doi: 10.3390/ijms232315205.