PMID- 36500345
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221221
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 23
DP  - 2022 Nov 26
TI  - Resveratrol Inhibits Proliferation and Induces Autophagy by Blocking SREBP1 
      Expression in Oral Cancer Cells.
LID - 10.3390/molecules27238250 [doi]
LID - 8250
AB  - Resveratrol is a polyphenolic antioxidant found in grapes, red wine, and peanuts 
      and has been reported to have anti-neoplastic effects on various cancer types. 
      However, the exact mechanism of its anti-cancer effects in oral cancer is not 
      fully understood and remains controversial. Resveratrol exhibits strong 
      hypolipidemic effects; therefore, we examined its effect on lipid metabolism in 
      oral cancer. Resveratrol significantly reduced cell viability and induced 
      autophagic cell death in oral cancer cells but not in normal cells. This 
      selective effect was accompanied by significantly reduced lipogenesis, which is 
      caused by downregulation of the transcription factor sterol regulatory 
      element-binding protein 1 (SREBP1) gene, followed by downregulation of the 
      epidermal fatty acid-binding protein (E-FABP). It was strongly suggested that 
      resveratrol-induced autophagy resulted from the inhibition of SREBP1-mediated 
      cell survival signaling. Luciferase reporter assay further indicated that 
      resveratrol has a potent and specific inhibitory effect on SREBP1-dependent 
      transactivation. Importantly, resveratrol markedly suppressed the growth of oral 
      cancer cells in an animal xenograft model, without exhibiting apparent 
      cytotoxicity. In conclusion, resveratrol induces autophagy in oral cancer cells 
      by suppressing lipid metabolism through the regulation of SREBP1 expression, 
      which highlights a novel mechanism of the anti-cancer effect of resveratrol.
FAU - Fukuda, Masakatsu
AU  - Fukuda M
AUID- ORCID: 0000-0002-5820-1679
AD  - Division of Biochemistry, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, Saitama 350-0283, Japan.
FAU - Ogasawara, Yudai
AU  - Ogasawara Y
AD  - Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, 
      Japan.
FAU - Hayashi, Hiroyasu
AU  - Hayashi H
AD  - Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, 
      Japan.
FAU - Inoue, Katsuyuki
AU  - Inoue K
AD  - Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, 
      Japan.
FAU - Sakashita, Hideaki
AU  - Sakashita H
AD  - Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, 
      Japan.
LA  - eng
GR  - 18K09822/the Ministry of Education, Science, and Culture of Japan/
PT  - Journal Article
DEP - 20221126
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Sterol Regulatory Element Binding Protein 1/metabolism
MH  - Resveratrol/pharmacology
MH  - Cell Line, Tumor
MH  - *Autophagy
MH  - Cell Proliferation
MH  - *Mouth Neoplasms/drug therapy
PMC - PMC9738393
OTO - NOTNLM
OT  - autophagy
OT  - epidermal fatty acid-binding protein
OT  - human oral squamous cell carcinoma
OT  - resveratrol
OT  - sterol regulatory element-binding protein 1
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/11/26
CRDT- 2022/12/11 01:26
PHST- 2022/10/17 00:00 [received]
PHST- 2022/11/17 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/11 01:26 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/26 00:00 [pmc-release]
AID - molecules27238250 [pii]
AID - molecules-27-08250 [pii]
AID - 10.3390/molecules27238250 [doi]
PST - epublish
SO  - Molecules. 2022 Nov 26;27(23):8250. doi: 10.3390/molecules27238250.