PMID- 36501019
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221221
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 23
DP  - 2022 Nov 24
TI  - Sleep Apnea and Cardiovascular Risk in Patients with Prediabetes and Type 2 
      Diabetes.
LID - 10.3390/nu14234989 [doi]
LID - 4989
AB  - Obstructive sleep apnea (OSA) is a common but largely undiagnosed clinical 
      condition, which is turning into a serious public health issue. Of note is that 
      its prevalence is gradually increasing in parallel with the obesity and type 2 
      diabetes mellitus (T2DM) epidemics. The aim of this article is to comprehensively 
      review the literature in order to evaluate the cardiovascular (CV) risk among 
      patients with OSA and prediabetes or T2DM. OSA seems to be an independent risk 
      factor for the development as well as the progression of T2DM, whereas it is 
      associated with T2DM-related macrovascular and microvascular complications. OSA 
      may also act as a potential risk factor for the presentation and development of 
      CV disease, such as hypertension, coronary artery disease, heart failure, 
      pulmonary hypertension, atrial fibrillation and other cardiac arrythmias, as well 
      as stroke. OSA and T2DM also share common pathophysiological mechanisms leading 
      to atherosclerosis. Considering that the coexistence of OSA and T2DM is an 
      independent and cumulative risk factor for CV mortality, more so than the two 
      diseases separately, clinicians and healthcare professionals should be aware of 
      and screen for OSA in patients with T2DM. Notably, targeted therapy for both 
      conditions seems to substantially improve CV prognosis.
FAU - Paschou, Stavroula A
AU  - Paschou SA
AUID- ORCID: 0000-0002-0651-1376
AD  - Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, 
      Alexandra Hospital, School of Medicine, National and Kapodistrian University of 
      Athens, 11528 Athens, Greece.
FAU - Bletsa, Evanthia
AU  - Bletsa E
AUID- ORCID: 0000-0003-3680-859X
AD  - 3rd Department of Cardiology, Sotiria Hospital, School of Medicine, National and 
      Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Saltiki, Katerina
AU  - Saltiki K
AUID- ORCID: 0000-0002-1421-0653
AD  - Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, 
      Alexandra Hospital, School of Medicine, National and Kapodistrian University of 
      Athens, 11528 Athens, Greece.
FAU - Kazakou, Paraskevi
AU  - Kazakou P
AD  - Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, 
      Alexandra Hospital, School of Medicine, National and Kapodistrian University of 
      Athens, 11528 Athens, Greece.
FAU - Kantreva, Kanella
AU  - Kantreva K
AD  - Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, 
      Alexandra Hospital, School of Medicine, National and Kapodistrian University of 
      Athens, 11528 Athens, Greece.
FAU - Katsaounou, Paraskevi
AU  - Katsaounou P
AD  - 1st Department of Critical Care Medicine, Evangelismos Hospital, School of 
      Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
FAU - Rovina, Nikoletta
AU  - Rovina N
AUID- ORCID: 0000-0003-0138-5582
AD  - 1st Department of Respiratory Medicine, Sotiria Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Trakada, Georgia
AU  - Trakada G
AUID- ORCID: 0000-0003-0037-1269
AD  - Respiratory Medicine Unit, Department of Clinical Therapeutics, Alexandra 
      Hospital, School of Medicine, National and Kapodistrian University of Athens, 
      11528 Athens, Greece.
FAU - Bakakos, Petros
AU  - Bakakos P
AD  - 1st Department of Respiratory Medicine, Sotiria Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Vlachopoulos, Charalambos V
AU  - Vlachopoulos CV
AD  - 1st Department of Cardiology, Hippokration Hospital, School of Medicine, National 
      and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Psaltopoulou, Theodora
AU  - Psaltopoulou T
AD  - Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, 
      Alexandra Hospital, School of Medicine, National and Kapodistrian University of 
      Athens, 11528 Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221124
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Cardiovascular Diseases/etiology/complications
MH  - Risk Factors
MH  - *Sleep Apnea Syndromes
MH  - *Sleep Apnea, Obstructive/complications/epidemiology
MH  - *Prediabetic State/complications/epidemiology
MH  - Heart Disease Risk Factors
MH  - *Atrial Fibrillation/complications
PMC - PMC9741445
OTO - NOTNLM
OT  - cardiovascular disease
OT  - diabetes
OT  - inflammation
OT  - obstructive sleep apnea
OT  - oxidative stress
OT  - prediabetes
OT  - vascular dysfunction
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/11/24
CRDT- 2022/12/11 01:31
PHST- 2022/11/06 00:00 [received]
PHST- 2022/11/19 00:00 [revised]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2022/12/11 01:31 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/24 00:00 [pmc-release]
AID - nu14234989 [pii]
AID - nutrients-14-04989 [pii]
AID - 10.3390/nu14234989 [doi]
PST - epublish
SO  - Nutrients. 2022 Nov 24;14(23):4989. doi: 10.3390/nu14234989.