PMID- 36501173
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221222
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 23
DP  - 2022 Dec 3
TI  - Maternal Supplementation with a Cocoa Extract during Lactation Deeply Modulates 
      Dams' Metabolism, Increases Adiponectin Circulating Levels and Improves the 
      Inflammatory Profile in Obese Rat Offspring.
LID - 10.3390/nu14235134 [doi]
LID - 5134
AB  - High-flavonoid cocoa consumption has been associated with beneficial properties. 
      However, there are scarce data concerning the effects of maternal cocoa intake on 
      dams and in their progeny. Here, we evaluated in rats whether maternal 
      supplementation with a high-flavan-3-ol cocoa extract (CCX) during lactation (200 
      mg.kg(-1).day(-1)) produced beneficial effects on dams and in their normoweight 
      (STD-CCX group) and cafeteria-fed obese (CAF-CCX group) adult male offspring. 
      Maternal intake of CCX significantly increased the circulating levels of 
      adiponectin and decreased the mammary gland lipid content of dams. These effects 
      were accompanied by increased energy expenditure and circulating free fatty 
      acids, as well as by a higher expression of lipogenic and adiponectin-related 
      genes in their mammary glands, which could be related to a compensatory mechanism 
      to ensure enough lipid supply to the pups. CCX consumption programmed both 
      offspring groups towards increased plasma total adiponectin levels, and decreased 
      liver weight and lean/fat ratio. Furthermore, CAF-CCX progeny showed an 
      improvement of the inflammatory profile, evidenced by the significant decrease of 
      the monocyte chemoattractant protein-1 (MCP-1) circulating levels and the mRNA 
      levels of the gene encoding the major histocompatibility complex, class II 
      invariant chain (Cd74), a marker of M1 macrophage phenotype, in the epididymal 
      white adipose tissue. Although further studies are needed, these findings can 
      pave the way for using CCX as a nutraceutical supplement during lactation.
FAU - Marine-Casado, Roger
AU  - Marine-Casado R
AUID- ORCID: 0000-0002-0924-4920
AD  - Eurecat, Centre Tecnologic de Catalunya, Technological Unit of Nutrition and 
      Health, 43204 Reus, Spain.
FAU - Domenech-Coca, Cristina
AU  - Domenech-Coca C
AD  - Eurecat, Centre Tecnologic de Catalunya, Technological Unit of Nutrition and 
      Health, 43204 Reus, Spain.
FAU - Crescenti, Anna
AU  - Crescenti A
AUID- ORCID: 0000-0001-8581-0616
AD  - Eurecat, Centre Tecnologic de Catalunya, Technological Unit of Nutrition and 
      Health, 43204 Reus, Spain.
FAU - Rodriguez Gomez, Miguel Angel
AU  - Rodriguez Gomez MA
AUID- ORCID: 0000-0001-9568-9821
AD  - Eurecat, Centre Tecnologic de Catalunya, Centre for Omic Sciences (COS), Joint 
      Unit Universitat Rovira i Virgili-EURECAT, 43204 Reus, Spain.
FAU - Del Bas, Josep Maria
AU  - Del Bas JM
AUID- ORCID: 0000-0002-0700-2004
AD  - Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
FAU - Arola, Lluis
AU  - Arola L
AUID- ORCID: 0000-0003-2767-1974
AD  - Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, 
      Universitat Rovira i Virgili, 43007 Tarragona, Spain.
FAU - Boque, Noemi
AU  - Boque N
AUID- ORCID: 0000-0001-7173-5512
AD  - Eurecat, Centre Tecnologic de Catalunya, Technological Unit of Nutrition and 
      Health, 43204 Reus, Spain.
FAU - Caimari, Antoni
AU  - Caimari A
AUID- ORCID: 0000-0001-6144-0294
AD  - Eurecat, Centre Tecnologic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
LA  - eng
GR  - AGL2010-19585/Ministry of Economy, Industry and Competitiveness/
GR  - CER-2019101/Centre for Industrial Technological Development/
GR  - TECCT11-1-0012/Agencia per a la Competitivitat de l'Empresa/
PT  - Journal Article
DEP - 20221203
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Adiponectin)
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Female
MH  - Rats
MH  - Male
MH  - Animals
MH  - Humans
MH  - *Adiponectin
MH  - Lactation/metabolism
MH  - Obesity/drug therapy/metabolism
MH  - Adipose Tissue, White/metabolism
MH  - Fatty Acids, Nonesterified/metabolism
MH  - *Cacao
MH  - Maternal Nutritional Physiological Phenomena
PMC - PMC9738144
OTO - NOTNLM
OT  - MCP-1
OT  - adiponectin
OT  - cocoa
OT  - inflammatory profile
OT  - lactation
OT  - maternal metabolism
OT  - metabolic programming
OT  - offspring
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/12 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/12/03
CRDT- 2022/12/11 01:32
PHST- 2022/11/04 00:00 [received]
PHST- 2022/11/25 00:00 [revised]
PHST- 2022/11/30 00:00 [accepted]
PHST- 2022/12/11 01:32 [entrez]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/12/03 00:00 [pmc-release]
AID - nu14235134 [pii]
AID - nutrients-14-05134 [pii]
AID - 10.3390/nu14235134 [doi]
PST - epublish
SO  - Nutrients. 2022 Dec 3;14(23):5134. doi: 10.3390/nu14235134.