PMID- 36502652
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230601
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 224
DP  - 2023 Jan
TI  - Clinical application of BIS combined with LCR in assessing brain function and 
      prognosis of patients with severe carbon monoxide poisoning.
PG  - 107556
LID - S0303-8467(22)00437-1 [pii]
LID - 10.1016/j.clineuro.2022.107556 [doi]
AB  - BACKGROUND: This study investigated the value of the bispectral index (BIS) and 
      lactate clearance rate (LCR) in the assessment of cerebral neurological injury 
      and prognosis in acute severe carbon monoxide poisoning (ASCOP) patients. 
      METHODS: A retrospective study was conducted on 86 ASCOP patients admitted to our 
      hospital from November 2019 to March 2021. The patients' prognosis neurological 
      function of the brain after 3 months of treatment was observed. The patients were 
      divided into good (48) and poor (38) groups according to the different prognoses. 
      The GCS-Pittsburgh score (G-P score) was performed on the patients after 
      admission. BIS and LCR were recorded at admission, 6 h, 24 h, 48 h, and 72 h 
      after admission. We conducted correlation and multivariate regression analysis 
      for each factor. ROC curves were used to assess the diagnostic efficacy of each 
      index on prognosis. RESULTS: The two different prognosis groups showed that there 
      were no significant differences for gender, age, treatment-free period, and 
      APACHE II score at admission (P > 0.05); the G-P score, the BIS, and LCR at 
      different times of admission was significantly higher in the good group than in 
      the poor group (all P < 0.05). Both the 24 h of BIS and the LCR were 
      diagnostically superior to the G-P score (P < 0.05); the diagnostic efficacy of 
      the two combined was not superior to that of the individual factors (AUC=0.787), 
      but had a high specificity (93.8 %). CONCLUSION: BIS monitoring and LCR have 
      clinical value in the assessment of neurological damage and prognostic in ASCOP 
      patients.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Shuangbao
AU  - Wang S
AD  - Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 
      053000, Hebei, China. Electronic address: sars_2002@126.com.
FAU - Liu, Yongjian
AU  - Liu Y
AD  - Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 
      053000, Hebei, China. Electronic address: 13932891561@163.com.
FAU - Liu, Huan
AU  - Liu H
AD  - Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 
      053000, Hebei, China. Electronic address: 15832828995@139.com.
FAU - Wang, Pu
AU  - Wang P
AD  - Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 
      053000, Hebei, China. Electronic address: wangpu02021@126.com.
FAU - Wang, Weizhan
AU  - Wang W
AD  - Department of Emergency Medicine, Harrison International Peace Hospital, Hengshui 
      053000, Hebei, China. Electronic address: wangweiz888@163.com.
LA  - eng
PT  - Journal Article
DEP - 20221207
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Humans
MH  - *Carbon Monoxide Poisoning/diagnosis/therapy
MH  - Lactic Acid
MH  - Retrospective Studies
MH  - *Brain Injuries
MH  - Brain/diagnostic imaging
MH  - ROC Curve
MH  - Prognosis
OTO - NOTNLM
OT  - Bispectral index
OT  - Brain nerve injury
OT  - Carbon monoxide poisoning
OT  - Lactate clearance rate
OT  - Prognosis
COIS- Conflict of interest The author promises that there is no conflict of interest in 
      this study.
EDAT- 2022/12/12 06:00
MHDA- 2023/05/22 06:42
CRDT- 2022/12/11 18:16
PHST- 2022/03/10 00:00 [received]
PHST- 2022/11/30 00:00 [revised]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2022/12/12 06:00 [pubmed]
PHST- 2022/12/11 18:16 [entrez]
AID - S0303-8467(22)00437-1 [pii]
AID - 10.1016/j.clineuro.2022.107556 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2023 Jan;224:107556. doi: 10.1016/j.clineuro.2022.107556. 
      Epub 2022 Dec 7.