PMID- 36502793
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240303
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 113
IP  - 12
DP  - 2023
TI  - Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old 
      Children.
PG  - 1232-1247
LID - 10.1159/000528631 [doi]
AB  - INTRODUCTION: Polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), and 
      per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants 
      (POPs) having numerous toxicological properties, including thyroid endocrine 
      disruption. Our aim was to assess the impact of POPs on thyroid hormones among 
      12-year-old children, while taking puberty into consideration. METHODS: Exposure 
      to 7 PCBs, 4 OCPs, and 6 PFASs (in microg/L), and free tri-iodothyronine (fT3, 
      pg/mL), free thyroxine (fT4, ng/dL), and thyroid-stimulating hormones (TSH, 
      mIU/L) were assessed through blood-serum measurements at age 12 years in 249 boys 
      and 227 girls of the PELAGIE mother-child cohort (France). Pubertal status was 
      clinically rated using the Tanner stages. For each POP, associations were 
      estimated using linear regression, adjusted for potential confounders. RESULTS: 
      Among boys, hexachlorobenzene and perfluorodecanoic acid were associated with 
      decreased fT3 (log-scale; beta [95% confidence interval] = -0.07 [-0.12,-0.02] and beta 
      = -0.03 [-0.06,-0.00], respectively). Intermediate levels of 
      perfluorohexanesulfonic acid (PFHxS) and PCB180 were associated, respectively, 
      with increased and decreased fT4. After stratification on pubertal status, PCBs 
      and OCPs were associated with decreased TSH only in the more advanced Tanner 
      stages (3-5) and with decreased fT3 among early Tanner stages (1-2). Among girls, 
      PFHxS was associated with decreased TSH (log-scale; beta = -0.15 [-0.29,-0.00]), and 
      perfluorooctanoic acid was associated with decreased fT3 (beta2nd_tercile = -0.06 
      [-0.10,-0.03] and beta3rd_tercile = -0.04 [-0.08,-0.00], versus. 1st tercile). 
      DISCUSSION: This cross-sectional study highlights associations between some POPs 
      and thyroid function disruption, which appears consistent with the literature. 
      Considering that the associations were sex-specific and moderated by pubertal 
      status in boys, complex endocrine interactions are likely involved.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Tillaut, Helene
AU  - Tillaut H
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, Rennes, France.
FAU - Monfort, Christine
AU  - Monfort C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, Rennes, France.
FAU - Giton, Frank
AU  - Giton F
AD  - AP-HP, Pole Biologie-Pathologie Henri Mondor, Creteil, France.
AD  - Inserm IMRB, Faculte de Sante, Creteil, France.
FAU - Warembourg, Charline
AU  - Warembourg C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, Rennes, France.
FAU - Rouget, Florence
AU  - Rouget F
AD  - Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, Rennes, France.
FAU - Cordier, Sylvaine
AU  - Cordier S
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, Rennes, France.
FAU - Laine, Fabrice
AU  - Laine F
AD  - CHU Rennes, Inserm CIC1414, Rennes, France.
FAU - Gaudreau, Eric
AU  - Gaudreau E
AD  - Centre de Toxicologie du Quebec (CTQ), Institut national de sante publique du 
      Quebec (INSPQ), Quebec, Quebec, Canada.
FAU - Garlantezec, Ronan
AU  - Garlantezec R
AD  - Inserm IMRB, Faculte de Sante, Creteil, France.
FAU - Saint-Amour, Dave
AU  - Saint-Amour D
AD  - Departement de Psychologie, Universite du Quebec a Montreal, Montreal, Quebec, 
      Canada.
AD  - Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, 
      Quebec, Canada.
FAU - Chevrier, Cecile
AU  - Chevrier C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, Rennes, France, cecile.chevrier@univ-rennes1.fr.
LA  - eng
PT  - Journal Article
DEP - 20221209
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Persistent Organic Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Thyroid Hormones)
RN  - 0 (Environmental Pollutants)
RN  - 9002-71-5 (Thyrotropin)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Fluorocarbons)
RN  - 355-46-4 (perfluorohexanesulfonic acid)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Child
MH  - Thyroid Gland
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
MH  - Cross-Sectional Studies
MH  - Thyroid Hormones
MH  - *Environmental Pollutants/toxicity
MH  - Thyrotropin
MH  - *Hydrocarbons, Chlorinated
MH  - *Fluorocarbons/toxicity
PMC - PMC10906475
OTO - NOTNLM
OT  - Adolescence
OT  - Per- and polyfluoroalkyl substances
OT  - Persistent organic pollutant
OT  - Thyroid function
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/12/13 06:00
MHDA- 2023/12/17 09:42
PMCR- 2022/12/09
CRDT- 2022/12/12 08:53
PHST- 2022/05/16 00:00 [received]
PHST- 2022/11/17 00:00 [accepted]
PHST- 2023/12/17 09:42 [medline]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/12 08:53 [entrez]
PHST- 2022/12/09 00:00 [pmc-release]
AID - 000528631 [pii]
AID - nen-0113-1232 [pii]
AID - 10.1159/000528631 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2023;113(12):1232-1247. doi: 10.1159/000528631. Epub 2022 Dec 
      9.