PMID- 36504568
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221221
IS  - 2008-2835 (Print)
IS  - 2008-4625 (Electronic)
IS  - 2008-2835 (Linking)
VI  - 14
IP  - 4
DP  - 2022 Oct-Dec
TI  - New Biomarkers in Early Diagnosis of Acute Kidney Injury in Children.
PG  - 264-269
AB  - Acute Kidney Injury (AKI) is a common condition with a high risk of mortality and 
      morbidity, so, early diagnosis and management of AKI is very important in 
      clinical practice. Despite significant progress in the management of AKI, it 
      still carries high morbidity and mortality. BUN and serum creatinine are not very 
      sensitive nor specific for the diagnosis of AKI because they are affected by many 
      renal and non-renal factors that are independent of kidney injury or kidney 
      function and change significantly only after significant kidney injury and with a 
      substantial time delay. Detection of biomarkers of AKI made predominantly by the 
      injured kidney tissue are essential for the early diagnosis of AKI. An ideal 
      biomarker should be one that could be easily measured, with no interference with 
      other biologic variables, and be able to clarify early phases of kidney damage. 
      The most common biomarkers studied are Neutrophil Gelatinase-Associated Lipocalin 
      (NGAL), Interleukin-18 (IL-18), Kidney Injury Molecule-1 (KIM-1), Cystatin-C, L 
      type Fatty Acid-Binding Protein (L-FABP), N-Acetyl-beta-D Glucosaminidase (NAG), 
      netrin-1, vanin-1, and Monocyte Chemoattractant Protein-1 (MCP-1) and 
      calprotectin.
CI  - Copyright(c) 2022 Avicenna Research Institute.
FAU - Bazargani, Behnaz
AU  - Bazargani B
AD  - Pediatric Chronic Kidney Disease Research Center, Department of Pediatric 
      Nephrology, Children Medical Center Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Moghtaderi, Mastaneh
AU  - Moghtaderi M
AD  - Pediatric Chronic Kidney Disease Research Center, Department of Pediatric 
      Nephrology, Children Medical Center Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Avicenna J Med Biotechnol
JT  - Avicenna journal of medical biotechnology
JID - 101511065
PMC - PMC9706243
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Biomarker
OT  - Calprotectin
OT  - Cystatin C
OT  - Interleukin-18
OT  - KIM-1
OT  - NGAL
EDAT- 2022/12/13 06:00
MHDA- 2022/12/13 06:01
PMCR- 2022/10/01
CRDT- 2022/12/12 10:44
PHST- 2022/05/15 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/12/12 10:44 [entrez]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/13 06:01 [medline]
PHST- 2022/10/01 00:00 [pmc-release]
AID - AJMB-14-264 [pii]
PST - ppublish
SO  - Avicenna J Med Biotechnol. 2022 Oct-Dec;14(4):264-269.