PMID- 36507087
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221221
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2022
DP  - 2022
TI  - The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of 
      Diabetic Kidney Disease.
PG  - 2550744
LID - 10.1155/2022/2550744 [doi]
LID - 2550744
AB  - BACKGROUND: Perirenal fat (PRF) has multiple effects on the kidney through its 
      physical structure and adipocytokine-secreting ability. The present study 
      explored the relationship between PRF thickness and the onset and progression of 
      albuminuria in patients with diabetes. METHODS: In the cross-sectional analysis, 
      we screened 959 patients from 8764 subjects with type 2 diabetes mellitus (T2DM) 
      who met the inclusion criteria and measured their perirenal fat thickness (PFT) 
      using color Doppler ultrasound. A group of laboratory indexes were included in 
      the analysis models. In a longitudinal study, a total of 218 patients with a 
      baseline UACR <30 mg/g were included in the follow-up study. RESULTS: In a 
      cross-sectional analysis, patients with diabetes and higher PFT presented with 
      higher albuminuria. Multiple logistic regression analysis indicated that PFT was 
      an independent risk factor for the degree of albuminuria in patients with T2DM 
      (odds ratio = 4.186, 95%CI: 2.290-7.653, P < 0.001). In a longitudinal study, 218 
      albuminuria-free patients with T2DM at the baseline were followed up for a mean 
      of 12.3 months. Based on the cutoff value from the ROC diagnostic test in the 
      cross-sectional study, patients were divided into two groups: higher PFT (H-PFT) 
      and lower PFT (L-PFT). Kaplan-Meier survival curve analysis showed that H-PFT was 
      associated with a higher incidence of albuminuria than L-PFT (log-rank test, 
      chi2 = 4.522, P = 0.033). Cox regression analysis showed that PFT was a risk factor 
      for the earlier onset of albuminuria (hazard ratio 2.83, 95% CI: 1.34-4.88, 
      P < 0.001). CONCLUSIONS: PRF evaluated by color Doppler ultrasound is an easy and 
      reliable tool for predicting the onset and progression of albuminuria in patients 
      with T2DM.
CI  - Copyright (c) 2022 Hongtu Hu et al.
FAU - Hu, Hongtu
AU  - Hu H
AUID- ORCID: 0000-0003-0754-2702
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
FAU - Liang, Wei
AU  - Liang W
AUID- ORCID: 0000-0002-1098-5662
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
FAU - Zhang, Zongwei
AU  - Zhang Z
AUID- ORCID: 0000-0002-6879-0470
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
FAU - Liu, Zikang
AU  - Liu Z
AUID- ORCID: 0000-0002-2061-7345
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
FAU - Chu, Fan
AU  - Chu F
AUID- ORCID: 0000-0001-6168-1119
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
FAU - Bao, Yan
AU  - Bao Y
AUID- ORCID: 0000-0001-7596-9885
AD  - Division of Endocrinology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
FAU - Ran, Jialu
AU  - Ran J
AUID- ORCID: 0000-0001-9263-8578
AD  - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30322, USA.
FAU - Ding, Guohua
AU  - Ding G
AUID- ORCID: 0000-0001-7477-5798
AD  - Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd, 
      Wuhan, Hubei 430060, China.
AD  - Key Clinical Research Center of Kidney Disease, 238 Jiefang Rd, Wuhan, Hubei 
      430060, China.
LA  - eng
PT  - Journal Article
DEP - 20221130
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC9729039
COIS- The authors declare no conflicts of interest.
EDAT- 2022/12/13 06:00
MHDA- 2022/12/13 06:01
PMCR- 2022/11/30
CRDT- 2022/12/12 11:30
PHST- 2022/04/08 00:00 [received]
PHST- 2022/09/19 00:00 [revised]
PHST- 2022/11/04 00:00 [accepted]
PHST- 2022/12/12 11:30 [entrez]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/13 06:01 [medline]
PHST- 2022/11/30 00:00 [pmc-release]
AID - 10.1155/2022/2550744 [doi]
PST - epublish
SO  - Int J Endocrinol. 2022 Nov 30;2022:2550744. doi: 10.1155/2022/2550744. 
      eCollection 2022.