PMID- 36507719
OWN - NLM
STAT- MEDLINE
DCOM- 20231121
LR  - 20231122
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 120
IP  - 1-2
DP  - 2023 Jan 9
TI  - Potentially Inadequate Medications in the Elderly: PRISCUS 2.0.
PG  - 3-10
LID - arztebl.m2022.0377 [pii]
LID - 10.3238/arztebl.m2022.0377 [doi]
AB  - BACKGROUND: The term potentially inadequate medication (PIM) is used to describe 
      substances that may be unsuitable for use inthe elderly and should be avoided. 
      The PRISCUS list, published in 2010, was the first catalog of PIM designed for 
      the Germandrug market to become adopted in practice. While 24% of German patients 
      aged >/= 65 years were prescribed at least one PIMper year in 2009, the proportion 
      in 2019 was only 14.5%. METHODS: In a three-round Delphi process, experts from 
      clinical practice and research evaluated whether selected substancesare PIM for 
      the elderly. The participants were provided with dedicated literature including 
      systematic reviews carried out for theparticular purposes of this project. 
      RESULTS: Fifty-nine persons took part in the Delphi process and, in addition, 
      contributed comments and therapeutic alternatives.Altogether, 187 substances were 
      classed as PIM. One hundred thirty-three of the substances now listed were not in 
      the originalPRISCUS list: these include some oral antidiabetics, all of the 
      selective COX-2 inhibitors, and moderately long acting benzodiazepinessuch as 
      oxazepam. For some other substances, e.g., proton pump inhibitors (PPI), the 
      advisability of treatment formore than 8 weeks was considered as potentially 
      inappropriate, as was the use of ibuprofen in doses >1200 mg/day and formore than 
      1 week without PPI. Risperidone for more than 6 weeks is also PIM. CONCLUSION: 
      The new, greatly extended PRISCUS list must now be validated in epidemiological 
      and prospective studies and itspracticability in routine daily use must be 
      verified.
FAU - Mann, Nina-Kristin
AU  - Mann NK
AD  - Chair of Clinical Pharmacology, Department of Medicine, Faculty of Health, 
      University of Witten/Herdecke; Institute of Medical Statistics, Faculty of 
      Medicine, University of Gottingen; Institute of Knowledge Management in Medicine, 
      Salzburg, Austria; Institute for Research in Operative Medicine, Department of 
      Medicine, Faculty of Health, University of Witten/Herdecke; Ludwig Boltzmann 
      Institute for Digital Health and Patient Safety, Medical University of Vienna, 
      Austria; Department of General and Family Medicine, Center for Public Health, 
      Medical University of Vienna, Austria; Philipp Klee Institute of Clinical 
      Pharmacology, Helios University Hospital, Wuppertal.
FAU - Mathes, Tim
AU  - Mathes T
FAU - Sonnichsen, Andreas
AU  - Sonnichsen A
FAU - Pieper, Dawid
AU  - Pieper D
FAU - Klager, Elisabeth
AU  - Klager E
FAU - Moussa, Mahmoud
AU  - Moussa M
FAU - Thurmann, Petra A
AU  - Thurmann PA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
RN  - 0 (Hypoglycemic Agents)
RN  - WK2XYI10QM (Ibuprofen)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Prospective Studies
MH  - *Hypoglycemic Agents
MH  - *Ibuprofen
MH  - Proton Pump Inhibitors
PMC - PMC10035347
EDAT- 2022/12/13 06:00
MHDA- 2023/11/21 06:42
PMCR- 2023/01/01
CRDT- 2022/12/12 11:48
PHST- 2022/09/12 00:00 [received]
PHST- 2022/09/12 00:00 [revised]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2023/11/21 06:42 [medline]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/12 11:48 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - arztebl.m2022.0377 [pii]
AID - 10.3238/arztebl.m2022.0377 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2023 Jan 9;120(1-2):3-10. doi: 10.3238/arztebl.m2022.0377.