PMID- 36509149
OWN - NLM
STAT- MEDLINE
DCOM- 20230127
LR  - 20230201
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 112
DP  - 2023 Feb
TI  - IgG4-IgE complex interferes with measurement of IgE concentration.
PG  - 11-16
LID - S0009-9120(22)00275-2 [pii]
LID - 10.1016/j.clinbiochem.2022.12.006 [doi]
AB  - BACKGROUND AND AIMS: Patients with immunoglobulin G4 (IgG4)-related disease 
      (IgG4-RD) have elevated immunoglobulin E (IgE) concentration compared to that in 
      healthy individuals, which suggests the occurrence of IgE-mediated allergic 
      reactions. We have previously shown that IgG4 and IgE form a complex in some 
      patients with IgG4-RD. However, it is currently unknown whether and how the 
      presence of the IgG4-IgE complex affects IgE concentration measurements by 
      different assays. MATERIALS AND METHODS: Twenty patients with confirmed presence 
      or absence of IgG4-IgE complex were evaluated. We compared IgE concentrations 
      measured by ST AIA-PACK IgE II (AIA-PACK), Elecsys IgE II Immunoassay (Elecsys), 
      and Iatroace IgE (Iatroace) and evaluated to what extent the IgG4-IgE complex 
      interfered with these measurements. RESULTS: In patients with the IgG4-IgE 
      complex, IgE concentrations measured using Iatroace were significantly lower than 
      those measured using Elecsys and tended to be lower than those measured using 
      AIA-PACK. IgE concentrations determined by Iatroace were significantly different 
      in patients with and without the IgG4-IgE complex, whereas no significant 
      differences between these groups were detected when IgE concentrations were 
      measured by AIA-PACK or Elecsys. CONCLUSION: The formation of the IgG4-IgE 
      complex underestimates measured IgE concentrations depending on the method used. 
      Therefore, caution should be exercised when selecting a specific IgE assay for 
      patients with IgG4-RD.
CI  - Copyright (c) 2022 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Nakano, Keiichi
AU  - Nakano K
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan; Department of Medical Technology and Sciences, School of Health 
      Sciences at Narita, International University of Health and Welfare, Chiba, Japan. 
      Electronic address: nkeiichi@frontier.hokudai.ac.jp.
FAU - Sugita, Junichi
AU  - Sugita J
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan.
FAU - Seimiya, Masanori
AU  - Seimiya M
AD  - Department of Medical Technology and Sciences, School of Health Sciences at 
      Narita, International University of Health and Welfare, Chiba, Japan.
FAU - Yasuda, Keiko
AU  - Yasuda K
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan.
FAU - Watanabe, Chiaki
AU  - Watanabe C
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan.
FAU - Goto, Hideki
AU  - Goto H
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan.
FAU - Teshima, Takanori
AU  - Teshima T
AD  - Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 
      Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20221209
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Humans
MH  - *Immunoglobulin E
MH  - Immunoglobulin G
MH  - *Immunoglobulin G4-Related Disease
OTO - NOTNLM
OT  - Discrepancy
OT  - IgG4-IgE complex
OT  - IgG4-related disease
OT  - Interference
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/13 06:00
MHDA- 2023/01/25 06:00
CRDT- 2022/12/12 19:23
PHST- 2022/07/19 00:00 [received]
PHST- 2022/11/25 00:00 [revised]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/12/12 19:23 [entrez]
AID - S0009-9120(22)00275-2 [pii]
AID - 10.1016/j.clinbiochem.2022.12.006 [doi]
PST - ppublish
SO  - Clin Biochem. 2023 Feb;112:11-16. doi: 10.1016/j.clinbiochem.2022.12.006. Epub 
      2022 Dec 9.