PMID- 36510177
OWN - NLM
STAT- MEDLINE
DCOM- 20221214
LR  - 20221222
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Dec 12
TI  - Association between uric acid level and contrast-induced acute kidney injury in 
      patients with type 2 diabetes mellitus after coronary angiography: a 
      retrospective cohort study.
PG  - 399
LID - 10.1186/s12882-022-03030-z [doi]
LID - 399
AB  - BACKGROUND: This study assessed the predictive value of uric acid (UA) for 
      contrast-induced acute kidney injury (CI-AKI) in patients with type 2 diabetes 
      mellitus (T2DM) who underwent coronary angiography (CAG). A nomogram to aid in 
      the prediction of CI-AKI was also developed and validated, and the construction 
      of a prognostic nomogram combined with clinical features was attempted. METHODS: 
      This study retrospectively enrolled T2DM patients who underwent CAG between 
      December 2019 and December 2020 at the Affiliated Zhongda Hospital of Southeast 
      University. Multivariable logistic regression analysis was used for the analysis 
      of clinical outcomes. Receiver operating characteristic (ROC) analyses were 
      performed to determine the area under the ROC curve (AUC) and the cut-off points 
      for continuous clinical data. The prediction accuracies of models for CI-AKI were 
      estimated through Harrell's concordance indices (C-index). Nomograms of the 
      prognostic models were plotted for individualized evaluations of CI-AKI in T2DM 
      patients after CAG. RESULTS: A total of 542 patients with T2DM who underwent CAG 
      were included in this study. We found that a high UA level (>/= 425.5 micromol/L; 
      OR = 6.303), BUN level (>/= 5.98 mmol/L; OR = 3.633), Scr level (>/= 88.5 micromol/L; 
      OR = 2.926) and HbA1C level (>/= 7.05%; OR = 5.509) were independent factors for 
      CI-AKI in T2DM patients after CAG. The nomogram model based on UA, BUN, Scr and 
      HbA1C levels presented outstanding performance for CI-AKI prediction (C-index: 
      0.878). Decision curve analysis (DCA) showed good clinical applicability in 
      predicting the incidence of CI-AKI in T2DM patients who underwent CAG. 
      CONCLUSION: High UA levels are associated with an increased incidence of CI-AKI 
      in T2DM patients after CAG. The developed nomogram model has potential predictive 
      value for CI-AKI and might serve as an economic and efficient prognostic tool in 
      clinical practice.
CI  - (c) 2022. The Author(s).
FAU - Tang, Haixia
AU  - Tang H
AD  - Institute of Nephrology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China.
FAU - Chen, Haoying
AU  - Chen H
AD  - Department of Ultrasonography, Taizhou central hospital, Taizhou university 
      hospital, Ningbo, China.
FAU - Li, Zuolin
AU  - Li Z
AD  - Institute of Nephrology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China.
FAU - Xu, Shengchun
AU  - Xu S
AD  - Institute of Nephrology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China.
FAU - Yan, Gaoliang
AU  - Yan G
AD  - Department of Cardiology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China.
FAU - Tang, Chengchun
AU  - Tang C
AD  - Department of Cardiology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China.
FAU - Liu, Hong
AU  - Liu H
AD  - Institute of Nephrology, Zhongda Hospital, Southeast University School of 
      Medicine, Nanjing, Jiangsu, China. jstzliu@sina.com.
LA  - eng
GR  - 82000648/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221212
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Humans
MH  - Coronary Angiography/adverse effects
MH  - Uric Acid
MH  - Retrospective Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Acute Kidney Injury/chemically induced/diagnostic imaging/epidemiology
PMC - PMC9746209
OTO - NOTNLM
OT  - Contrast induced-acute kidney injury
OT  - Coronary angiology
OT  - Nomogram
OT  - Type 2 diabetes mellitus
OT  - Uric acid
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/13 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/12/12
CRDT- 2022/12/12 23:46
PHST- 2022/08/06 00:00 [received]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2022/12/12 23:46 [entrez]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/12/12 00:00 [pmc-release]
AID - 10.1186/s12882-022-03030-z [pii]
AID - 3030 [pii]
AID - 10.1186/s12882-022-03030-z [doi]
PST - epublish
SO  - BMC Nephrol. 2022 Dec 12;23(1):399. doi: 10.1186/s12882-022-03030-z.