PMID- 36510223
OWN - NLM
STAT- MEDLINE
DCOM- 20221214
LR  - 20230108
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 21
IP  - 1
DP  - 2022 Dec 12
TI  - Predictive effect of triglyceride-glucose index on clinical events in patients 
      with acute ischemic stroke and type 2 diabetes mellitus.
PG  - 280
LID - 10.1186/s12933-022-01704-4 [doi]
LID - 280
AB  - BACKGROUND: The triglyceride-glucose (TyG) index was significantly related to 
      clinical outcome in patients with cardiovascular disease (CAD) and 
      cerebrovascular disease (CVD). We aim to investigate the association between TyG 
      index and clinical prognosis of acute ischemic stroke (IS) patients with type-2 
      diabetes mellitus (T2DM). METHODS: Among 19,604 patients with acute IS admitted 
      to the China National Stroke Registry II (CNSRII), 3359 IS patients with T2DM 
      were included in the cross-sectional analysis. The TyG index (calculated by ln 
      [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]) was split into four 
      quartiles. The outcomes included recurrent IS, all-cause death and poor outcome 
      at 1 year were analyzed. The association between the TyG index and adverse 
      cerebrovascular outcomes was assessed by proportional hazards regression 
      analysis. RESULTS: During 1 year follow-up, recurrent IS, all-cause death and 
      poor outcome occurred in 305 (9.08%), 229 (6.82%) and 443 (47.9%) cases, 
      respectively. Multivariable Cox proportional hazards analyses showed that the 
      risk of incident primary endpoints was associated with a higher TyG quartile. 
      After adjustment for confounding factors, patients with a higher TyG index had an 
      association with IS recurrence (adjusted hazard ratio, 1.41; 95% confidence 
      interval, 0.97-2.03; P = 0.048) and all-cause death (adjusted hazard ratio, 1.70; 
      95% confidence interval, 1.062-2.74; P = 0.028), compared with those in the first 
      quartile at 1 year time follow-up. In addition, there were interactions between 
      TyG index and age (>/= 65), female, hypertensive agents, anticoagulant agents, 
      statins and antidiabetic agents in subgroup analyses, especially patients without 
      taken anticoagulant drugs were significantly related to IS recurrence, all-cause 
      death and poor outcome (P = 0.003, P = 0.006 and P = 0.001, respectively). 
      CONCLUSIONS: TyG index is strongly related to the IS recurrence and all-cause 
      death in acute IS patients with T2DM. This finding indicates that the TyG 
      index might be a potential predictor of clinical outcome for acute IS patients 
      with T2DM.
CI  - (c) 2022. The Author(s).
FAU - Liu, Dong
AU  - Liu D
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, 100070, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China.
FAU - Yang, Kaixuan
AU  - Yang K
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China.
FAU - Gu, Hongqiu
AU  - Gu H
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China.
FAU - Li, Zixiao
AU  - Li Z
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, 100070, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China.
FAU - Wang, Yongjun
AU  - Wang Y
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, 100070, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China.
AD  - Advanced Innovation Center for Human Brain Protection, Capital Medical 
      University, Beijing, 100070, China.
AD  - Clinical Center for Precision Medicine in Stroke, Capital Medical University, 
      Beijing, 100070, China.
FAU - Wang, Yilong
AU  - Wang Y
AD  - Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, 100070, China. yilong528@gmail.com.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      100070, China. yilong528@gmail.com.
AD  - Advanced Innovation Center for Human Brain Protection, Capital Medical 
      University, Beijing, 100070, China. yilong528@gmail.com.
AD  - Clinical Center for Precision Medicine in Stroke, Capital Medical University, 
      Beijing, 100070, China. yilong528@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221212
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Triglycerides)
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/drug therapy
MH  - Triglycerides
MH  - Blood Glucose
MH  - Glucose
MH  - Cross-Sectional Studies
MH  - *Ischemic Stroke/diagnosis
MH  - Risk Factors
MH  - Retrospective Studies
MH  - Biomarkers
MH  - Risk Assessment
PMC - PMC9743618
OTO - NOTNLM
OT  - Ischemic stroke
OT  - Prognosis
OT  - The triglyceride-glucose index
OT  - Type-2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/13 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/12/12
CRDT- 2022/12/12 23:49
PHST- 2022/07/06 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/12/12 23:49 [entrez]
PHST- 2022/12/13 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/12/12 00:00 [pmc-release]
AID - 10.1186/s12933-022-01704-4 [pii]
AID - 1704 [pii]
AID - 10.1186/s12933-022-01704-4 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2022 Dec 12;21(1):280. doi: 10.1186/s12933-022-01704-4.