PMID- 36512074
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230613
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 78
IP  - 4
DP  - 2023 Mar 30
TI  - Operationalization of Intrinsic Capacity in Older People and Its Association With 
      Subsequent Disability, Hospital Admission and Mortality: Results From The English 
      Longitudinal Study of Ageing.
PG  - 698-703
LID - 10.1093/gerona/glac250 [doi]
AB  - BACKGROUND: Intrinsic capacity (IC) is a new concept in the healthy aging field 
      and has many operationalized definitions. In this study, we operationalized IC 
      using item response theory in the English Longitudinal Study of Ageing (ELSA) and 
      tested the predictive value of the scale using a subsequent functional ability, 
      mortality, and hospital admission. METHODS: IC was measured at baseline (2004, 
      Wave 2) using 14 dichotomous indicators: word recall, orientation in time, 
      balance, chair rises, walking speed, upper mobility, lower mobility, eyesight, 
      hearing, grip strength, body mass index, waist circumference, depressive 
      symptoms, and life satisfaction. A 2-parameter item response theory model was 
      used to generate a scale of IC at baseline. Logistic regression was used for the 
      prediction of subsequent difficulties, measured by difficulties with >/=1 
      activities of daily living (ADLs) and >/=1 instrumental activities of daily living 
      (IADLs) at 4 and 8 years after baseline. Competing risk and Cox regressions were 
      employed to test the prediction of hospital admission and mortality, 
      respectively, over a 14-year follow-up. RESULTS: IC scores were generated for 4 
      545 individuals aged on average 70.8 years (standard deviation [SD] 7.93). Better 
      baseline IC scores were associated with reduced risk of subsequent difficulties 
      with ADLs and IADLs, hospital admission (subdistribution hazard ratios [SHR] = 
      0.99, 95% confidence interval [CI] 0.98-0.99), and mortality (hazard ratios [HR] 
      = 0.98, 95% CI 0.98-0.99), when adjusted for sociodemographic and health-related 
      covariates. CONCLUSION: These results suggest the utility of this IC score as a 
      measure of risk for future adverse outcomes in older people, potentially above 
      that indicated by other sociodemographic and health-related factors.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of The 
      Gerontological Society of America.
FAU - Campbell, Charlotte L
AU  - Campbell CL
AUID- ORCID: 0000-0002-4185-5430
AD  - Department of Epidemiology and Public Health, University College London and 
      CLOSER, Social Research Institute, University College London, London, UK.
FAU - Cadar, Dorina
AU  - Cadar D
AUID- ORCID: 0000-0003-1398-5841
AD  - Centre for Dementia Studies, Brighton and Sussex Medical School and Department of 
      Behavioural Science and Health, University College London, London, UK.
FAU - McMunn, Anne
AU  - McMunn A
AD  - Department of Epidemiology and Public Health, University College London, London, 
      UK.
FAU - Zaninotto, Paola
AU  - Zaninotto P
AUID- ORCID: 0000-0003-3036-0499
AD  - Department of Epidemiology and Public Health, University College London, London, 
      UK.
LA  - eng
GR  - R01AG017644/AG/NIA NIH HHS/United States
GR  - 198-1074/DH_/Department of Health/United Kingdom
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Humans
MH  - Aged
MH  - Longitudinal Studies
MH  - *Activities of Daily Living
MH  - *Aging/physiology
MH  - Hospitalization
MH  - Hospitals
PMC - PMC10061563
OTO - NOTNLM
OT  - Dependence
OT  - Index
OT  - Survival
COIS- None declared.
EDAT- 2022/12/14 06:00
MHDA- 2023/03/31 06:42
PMCR- 2022/12/13
CRDT- 2022/12/13 11:14
PHST- 2022/04/21 00:00 [received]
PHST- 2023/03/31 06:42 [medline]
PHST- 2022/12/14 06:00 [pubmed]
PHST- 2022/12/13 11:14 [entrez]
PHST- 2022/12/13 00:00 [pmc-release]
AID - 6895372 [pii]
AID - glac250 [pii]
AID - 10.1093/gerona/glac250 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):698-703. doi: 
      10.1093/gerona/glac250.