PMID- 36514263
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221222
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 28
DP  - 2022 Dec 14
TI  - Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with 
      Elevated Tryptase Levels.
PG  - e937990
LID - 10.12659/MSM.937990 [doi]
AB  - BACKGROUND In this paper we report on the link between increased tryptase levels 
      and prevalence of allergen-specific immunoglobulin E (IgE) in patients with 
      anaphylaxis. The main aim of the study was to assess the corelation between 
      elevated tryptase levels and allergen-specific immunoglobulin E (IgE) in 
      anaphylactic reactions, mastocytosis, and other types of allergic reactions. 
      MATERIAL AND METHODS We enrolled 60 adult patients, aged 18-68 years (mean age 
      45+/-8 years). The subjects were divided into 3 groups (20 patients in each group) 
      according to the serum tryptase changes: group 1 consisted of patients with 
      anaphylaxis (serum tryptase level >/=11.4 microg/l), group 2 consisted of patients with 
      mastocytosis (serum tryptase level >/=20.0 microg/l), and group 3 consisted of patients 
      with other allergic reactions with no anaphylaxis as an atopic control group 
      (serum tryptase level <11.4 microg/l). The test material was venous blood serum 
      samples. The allergen-specific IgE assay was carried out by immunoblot. Tryptase 
      concentration was determined by immunoenzymatic assay. RESULTS Allergen-specific 
      IgE was found in 73% of all subjects: 75% in the anaphylactic group, 55% in the 
      mastocytosis group, and 90% in the atopic control group. Polysensitization was 
      common and was significantly different among groups. In the atopic group, there 
      were more patients allergic to 4-7 allergens (P<0.05). CONCLUSIONS We did not 
      find a strong correlation between allergen-specific IgE levels and elevated 
      tryptase levels.
FAU - Cerniauskiene, Mege
AU  - Cerniauskiene M
AD  - Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 
      Vilnius, Lithuania.
AD  - JSC "Imunodiagnostika", Vilnius, Lithuania.
FAU - Bagdonaite, Loreta
AU  - Bagdonaite L
AD  - Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 
      Vilnius, Lithuania.
FAU - Karciauskaite, Dovile
AU  - Karciauskaite D
AD  - Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 
      Vilnius, Lithuania.
FAU - Kvedariene, Violeta
AU  - Kvedariene V
AD  - Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 
      Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20221214
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - EC 3.4.21.59 (Tryptases)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Tryptases
MH  - Prevalence
MH  - Immunoglobulin E
MH  - *Anaphylaxis
MH  - *Mastocytosis
MH  - Allergens
PMC - PMC9762103
COIS- Conflict of interest: None declared
EDAT- 2022/12/15 06:00
MHDA- 2022/12/16 06:00
PMCR- 2022/12/14
CRDT- 2022/12/14 01:23
PHST- 2022/12/14 01:23 [entrez]
PHST- 2022/12/15 06:00 [pubmed]
PHST- 2022/12/16 06:00 [medline]
PHST- 2022/12/14 00:00 [pmc-release]
AID - 937990 [pii]
AID - 10.12659/MSM.937990 [doi]
PST - epublish
SO  - Med Sci Monit. 2022 Dec 14;28:e937990. doi: 10.12659/MSM.937990.