PMID- 36514765
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221221
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 10
IP  - 12
DP  - 2022 Dec
TI  - Study on dietary intake, risk assessment, and molecular toxicity mechanism of 
      benzo[alpha]pyrene in college students in China Bashu area.
PG  - 4155-4167
LID - 10.1002/fsn3.3007 [doi]
AB  - As an extremely strong polycyclic aromatic hydrocarbon carcinogen, benzo[alpha]pyrene 
      (BaP) is often produced during food processing at high temperatures. Recently, 
      food safety, as well as toxicity mechanism and risk assessment of BaP, has 
      received extensive attention. We first constructed the database of BaP pollution 
      concentration in Chinese daily food with over 10(4) data items; collected dietary 
      intake data using online survey; then assessed dietary exposure risk; and finally 
      revealed the possible toxicity mechanism through four comparative molecular 
      dynamics (MD) simulations. The statistical results showed that the concentration 
      of BaP in olive oil was the highest, followed by that in fried meat products. The 
      margins of exposure and incremental lifetime cancer risk both indicated that the 
      dietary exposure to BaP of the participants was generally safe, but there were 
      still some people with certain carcinogenic risks. Specifically, the health risk 
      of the core district population was higher than that of the noncore district in 
      Bashu area, and the female postgraduate group was higher than the male group with 
      bachelor degree or below. From MD trajectories, BaP binding does not affect the 
      global motion of individual nucleic acid sequences, but local weak noncovalent 
      interactions changed greatly; it also weakens molecular interactions of nucleic 
      acid with Bacillus stearothermophilus DNA polymerase I large fragment (BF), and 
      significantly changes the cavity structure of recognition interface. This work 
      not only reveals the possible toxicity mechanism of BaP, but also provides 
      theoretical guidance for the subsequent optimization of food safety standards and 
      reference of rational diet.
CI  - (c) 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Ge, Yutong
AU  - Ge Y
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Yan, Hailian
AU  - Yan H
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Shi, Xiaodong
AU  - Shi X
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Wu, Zhixiang
AU  - Wu Z
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Wang, Yueteng
AU  - Wang Y
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Zhang, Zelan
AU  - Zhang Z
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Luo, Qing
AU  - Luo Q
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Liu, Wei
AU  - Liu W
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Liang, Li
AU  - Liang L
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Peng, Lianxin
AU  - Peng L
AUID- ORCID: 0000-0002-3555-6274
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
FAU - Hu, Jianping
AU  - Hu J
AUID- ORCID: 0000-0001-7367-3968
AD  - Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural 
      Affairs, School of Pharmacy, Sichuan Industrial Institute of Antibiotics Chengdu 
      University Chengdu China.
LA  - eng
PT  - Journal Article
DEP - 20220809
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC9731532
OTO - NOTNLM
OT  - benzo[alpha]pyrene
OT  - daily intake
OT  - molecular dynamics simulation
OT  - risk assessment
OT  - toxicity mechanism
COIS- All the authors declare no conflict of interest, financial or otherwise.
EDAT- 2022/12/15 06:00
MHDA- 2022/12/15 06:01
PMCR- 2022/08/09
CRDT- 2022/12/14 02:00
PHST- 2021/10/12 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/14 00:00 [accepted]
PHST- 2022/12/14 02:00 [entrez]
PHST- 2022/12/15 06:00 [pubmed]
PHST- 2022/12/15 06:01 [medline]
PHST- 2022/08/09 00:00 [pmc-release]
AID - FSN33007 [pii]
AID - 10.1002/fsn3.3007 [doi]
PST - epublish
SO  - Food Sci Nutr. 2022 Aug 9;10(12):4155-4167. doi: 10.1002/fsn3.3007. eCollection 
      2022 Dec.