PMID- 36514835
OWN - NLM
STAT- MEDLINE
DCOM- 20230104
LR  - 20230111
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 36
IP  - 1
DP  - 2023 Dec
TI  - High prevalence of maternal mosaic monosomy X in pregnant women in Vietnam.
PG  - 2155044
LID - 10.1080/14767058.2022.2155044 [doi]
AB  - OBJECTIVE: To demonstrate the prevalence of maternal mosaic monosomy X (MMXO) in 
      a cohort of pregnant women in Vietnam. METHODS: All 105,594 singleton pregnant 
      women undergoing noninvasive prenatal screening (NIPS) between January 2019 and 
      February 2021 in Vietnam were analyzed by measuring discordance between size- and 
      count-based z-scores for chromosome X (ChrX) to identify suspected cases of MMXO 
      and validated by fluorescence in situ hybridization (FISH) on maternal blood. 
      RESULTS: We identified 295 (0.279%) suspected MMXO cases. After FISH analysis, 
      MMXO was confirmed in 125 cases (42.37%), revealing the MMXO prevalence of 0.118% 
      (95% CI: 0.097-0.139%) in this cohort. CONCLUSION: We found a relatively high 
      prevalence of MMXO in Vietnamese pregnant women and demonstrated a strong 
      influence of MMXO on the ChrX z-score using a count-based method, resulting in 
      false positives. The size-based method is not sensitive to MMXO and therefore 
      achieves higher PPV.
FAU - Tran, Danh Cuong
AU  - Tran DC
AD  - Department of Obstetrics and Gynecology, National Hospital of Obstetrics and 
      Gynecology, Hanoi, Vietnam.
AD  - Department of Obstetrics and Gynecology Department, Hanoi Medical University, 
      Hanoi, Vietnam.
FAU - Nguyen, Thanh-Thanh Thi
AU  - Nguyen TT
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Thi Hoang, Ngoc-Lan
AU  - Thi Hoang NL
AD  - Department of Obstetrics and Gynecology, National Hospital of Obstetrics and 
      Gynecology, Hanoi, Vietnam.
AD  - Department of Obstetrics and Gynecology Department, Hanoi Medical University, 
      Hanoi, Vietnam.
FAU - Thi Luong, Lan-Anh
AU  - Thi Luong LA
AD  - Department of Obstetrics and Gynecology Department, Hanoi Medical University, 
      Hanoi, Vietnam.
FAU - Doan, Kim-Phuong Thi
AU  - Doan KT
AD  - Department of Obstetrics and Gynecology, National Hospital of Obstetrics and 
      Gynecology, Hanoi, Vietnam.
AD  - Department of Obstetrics and Gynecology Department, Hanoi Medical University, 
      Hanoi, Vietnam.
FAU - Ha, Minh Thi Thi
AU  - Ha MTT
AUID- ORCID: 0000-0003-3803-9472
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy, Hue 
      University, Hue, Vietnam.
FAU - Tran, Nhat-Thang
AU  - Tran NT
AD  - Obstetrics and Gynecology Department, University Medical Center HCMC, Ho Chi Minh 
      City, Vietnam.
FAU - Nguyen, Van-Thong
AU  - Nguyen VT
AUID- ORCID: 0000-0001-9202-1092
AD  - Medical Genetics Department, Hung Vuong Hospital, Ho Chi Minh City, Vietnam.
FAU - Trinh, Thu-Huong Nhat
AU  - Trinh TN
AD  - Department of Antenatal Care, Tu Du Hospital, Ho Chi Minh City, Vietnam.
FAU - Kieu Nguyen, Ngoc-Trinh
AU  - Kieu Nguyen NT
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Cong-Trai
AU  - Nguyen CT
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Thanh-Dat
AU  - Nguyen TD
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Thi Nguyen, xQuynh-Tho
AU  - Thi Nguyen XT
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
FAU - Do, Thanh-Thuy Thi
AU  - Do TT
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
FAU - Truong, Dinh-Kiet
AU  - Truong DK
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
FAU - Giang, Hoa
AU  - Giang H
AUID- ORCID: 0000-0001-6549-8012
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Hoai-Nghia
AU  - Nguyen HN
AD  - Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
FAU - Tang, Hung-Sang
AU  - Tang HS
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
FAU - Phan, Minh-Duy
AU  - Phan MD
AUID- ORCID: 0000-0002-3426-1044
AD  - Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam.
AD  - Genetic Counselling, Gene Solutions, Ho Chi Minh City, Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20221213
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Turner Syndrome/diagnosis/epidemiology/genetics
MH  - Pregnant Women
MH  - In Situ Hybridization, Fluorescence
MH  - Vietnam/epidemiology
MH  - Prevalence
MH  - Prenatal Diagnosis/methods
OTO - NOTNLM
OT  - Maternal mosaic monosomy
OT  - Vietnam
OT  - chromosome X
OT  - pregnant women
OT  - z-score
EDAT- 2022/12/15 06:00
MHDA- 2023/01/05 06:00
CRDT- 2022/12/14 02:23
PHST- 2022/12/15 06:00 [pubmed]
PHST- 2023/01/05 06:00 [medline]
PHST- 2022/12/14 02:23 [entrez]
AID - 10.1080/14767058.2022.2155044 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2023 Dec;36(1):2155044. doi: 
      10.1080/14767058.2022.2155044. Epub 2022 Dec 13.