PMID- 36516778
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20240214
IS  - 2211-1247 (Electronic)
VI  - 41
IP  - 11
DP  - 2022 Dec 13
TI  - Consumption of fish oil high-fat diet induces murine hair loss via epidermal 
      fatty acid binding protein in skin macrophages.
PG  - 111804
LID - S2211-1247(22)01692-8 [pii]
LID - 10.1016/j.celrep.2022.111804 [doi]
AB  - Fats are essential in healthy diets, but how dietary fats affect immune cell 
      function and overall health is not well understood. Mimicking human high-fat 
      diets (HFDs), which are rich in different fatty acid (FA) components, we fed mice 
      various HFDs from different fat sources, including fish oil and cocoa butter. 
      Mice consuming the fish oil HFD exhibit a hair-loss phenotype. Further studies 
      show that omega-3 (n-3) FAs in fish oil promote atypical infiltration of CD207(-) 
      (langerin(-)) myeloid macrophages in skin dermis, which induce hair loss through 
      elevated TNF-alpha signaling. Mechanistically, epidermal fatty acid binding protein 
      (E-FABP) is demonstrated to play an essential role in inducing TNF-alpha-mediated 
      hair loss by activating the n-3 FA/ROS/IL-36 signaling pathway in dermal resident 
      macrophages. Absence of E-FABP abrogates fish oil HFD-induced murine hair loss. 
      Altogether, these findings support a role for E-FABP as a lipid sensor mediating 
      n-3 FA-regulated macrophage function and skin health.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hao, Jiaqing
AU  - Hao J
AD  - Department of Pathology, University of Iowa, 431 Newton Road, Iowa City, IA, USA; 
      Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA.
FAU - Jin, Rong
AU  - Jin R
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA; NHC Key Laboratory of Medical Immunology, Department of Immunology, 
      School of Basic Medical Sciences, Peking University, Beijing, China.
FAU - Zeng, Jun
AU  - Zeng J
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA; School of Basic Medical Sciences, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Hua, Yuan
AU  - Hua Y
AD  - Department of Pathology, University of Iowa, 431 Newton Road, Iowa City, IA, USA; 
      Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA.
FAU - Yorek, Matthew S
AU  - Yorek MS
AD  - Department of Pathology, University of Iowa, 431 Newton Road, Iowa City, IA, USA.
FAU - Liu, Lianliang
AU  - Liu L
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA; College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 
      China.
FAU - Mandal, Anita
AU  - Mandal A
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA.
FAU - Li, Junling
AU  - Li J
AD  - Department of Radiology, University of Louisville, Louisville, KY, USA.
FAU - Zheng, Huaiyu
AU  - Zheng H
AD  - Department of Radiology, University of Louisville, Louisville, KY, USA.
FAU - Sun, Yanwen
AU  - Sun Y
AD  - Department of Pathology, University of Iowa, 431 Newton Road, Iowa City, IA, USA; 
      Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA.
FAU - Yi, Yanmei
AU  - Yi Y
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA; Department of Histology and Embryology, Guangdong Medical University, 
      Zhanjiang, China.
FAU - Yin, Di
AU  - Yin D
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA; School of Basic Medical Sciences, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Zheng, Qi
AU  - Zheng Q
AD  - Bioinformatics and Biostatistics, Department of Public Health, University of 
      Louisville, Louisville, KY, USA.
FAU - Li, Xiaohong
AU  - Li X
AD  - Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, 
      Department of Anatomical Sciences and Neurobiology, University of Louisville, 
      Louisville, KY, USA.
FAU - Ng, Chin K
AU  - Ng CK
AD  - Department of Radiology, University of Louisville, Louisville, KY, USA.
FAU - Rouchka, Eric C
AU  - Rouchka EC
AD  - Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, 
      Department of Anatomical Sciences and Neurobiology, University of Louisville, 
      Louisville, KY, USA; Department of Computer Science and Engineering, University 
      of Louisville, Louisville, KY, USA.
FAU - Egilmez, Nejat K
AU  - Egilmez NK
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA.
FAU - Jabbari, Ali
AU  - Jabbari A
AD  - Department of Dermatology, University of Iowa, Iowa City, IA, USA; Iowa City VA 
      Medical Center, Iowa City, IA, USA.
FAU - Li, Bing
AU  - Li B
AD  - Department of Pathology, University of Iowa, 431 Newton Road, Iowa City, IA, USA; 
      Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, USA. Electronic address: bing-li@uiowa.edu.
LA  - eng
GR  - R01 AI137324/AI/NIAID NIH HHS/United States
GR  - P20 GM103436/GM/NIGMS NIH HHS/United States
GR  - P30 GM106396/GM/NIGMS NIH HHS/United States
GR  - P20 GM135004/GM/NIGMS NIH HHS/United States
GR  - U01 CA272424/CA/NCI NIH HHS/United States
GR  - R01 CA180986/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Fish Oils)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Mice
MH  - Humans
MH  - Animals
MH  - *Fish Oils/pharmacology/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Dietary Fats/pharmacology
MH  - Macrophages/metabolism
MH  - Fatty Acid-Binding Proteins/genetics/metabolism
MH  - *Fatty Acids, Omega-3/metabolism
MH  - Alopecia/metabolism
PMC - PMC10193786
MID - NIHMS1857925
OTO - NOTNLM
OT  - CP: Immunology
OT  - CP: Metabolism
OT  - fatty acid binding protein
OT  - fish oil
OT  - hair loss
OT  - high-fat diet
OT  - macrophages
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/12/15 06:00
MHDA- 2022/12/17 06:00
PMCR- 2023/05/18
CRDT- 2022/12/14 18:34
PHST- 2022/06/27 00:00 [received]
PHST- 2022/10/06 00:00 [revised]
PHST- 2022/11/18 00:00 [accepted]
PHST- 2022/12/14 18:34 [entrez]
PHST- 2022/12/15 06:00 [pubmed]
PHST- 2022/12/17 06:00 [medline]
PHST- 2023/05/18 00:00 [pmc-release]
AID - S2211-1247(22)01692-8 [pii]
AID - 10.1016/j.celrep.2022.111804 [doi]
PST - ppublish
SO  - Cell Rep. 2022 Dec 13;41(11):111804. doi: 10.1016/j.celrep.2022.111804.