PMID- 36517997
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230403
IS  - 1600-051X (Electronic)
IS  - 0303-6979 (Linking)
VI  - 50
IP  - 4
DP  - 2023 Apr
TI  - Acute-phase response following one-stage full-mouth versus quadrant non-surgical 
      periodontal treatment in subjects with comorbid type 2 diabetes: A randomized 
      clinical trial.
PG  - 487-499
LID - 10.1111/jcpe.13760 [doi]
AB  - AIM: To compare the level of inflammatory markers and endothelial function 24 h 
      (Day 1) and 90 days (Day 90) after conventional quadrant-wise scaling and root 
      planing (Q-SRP) versus one-stage full-mouth SRP (FM-SRP) in patients affected by 
      type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Patients affected by 
      periodontitis and T2DM were randomly allocated to receive FM-SRP or Q-SRP and 
      followed up at Day 1 and Day 90. Serum samples, vital signs, and flow-mediated 
      dilation (FMD) parameters were collected at baseline, Day 1, and Day 90. 
      Periodontal variables were collected at baseline and Day 90. The primary outcome 
      was the C-reactive protein (CRP) concentration at Day 1 after periodontal 
      treatment. Student's t-test for independent samples was used for between-group 
      comparisons (Mann-Whitney U test for non-normal data), while analysis of variance 
      with post hoc Tukey tests (Kruskal-Wallis and Dunn tests for non-normal data) 
      were used for intra-group comparisons. RESULTS: Forty subjects were included in 
      the study. FM-SRP produced a significant increase in CRP and a significant 
      reduction in FMD at Day 1 compared to Q-SRP (p < .05). The absolute change in 
      HbA1c (mmol/mol) from baseline to Day 90 was significantly improved in the Q-SRP 
      (DeltaHbA1c = -1.59 [SD = 1.20]) compared to the FM-SRP group (DeltaHbA1c = -0.8 
      [SD = 0.95]) (p = .04). CONCLUSIONS: FM-SRP triggers a robust acute-phase 
      response at 24 h after treatment compared to Q-SRP. Such systemic acute 
      perturbations may offset the beneficial systemic effects of periodontal treatment 
      in terms of HbA1c reduction and improvement in endothelial function in T2DM 
      subjects.
CI  - (c) 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Graziani, Filippo
AU  - Graziani F
AUID- ORCID: 0000-0001-8780-7306
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University 
      Hospital of Pisa, Pisa, Italy.
FAU - Gennai, Stefano
AU  - Gennai S
AUID- ORCID: 0000-0002-1554-9966
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University 
      Hospital of Pisa, Pisa, Italy.
FAU - Marruganti, Crystal
AU  - Marruganti C
AUID- ORCID: 0000-0003-1088-2046
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University 
      Hospital of Pisa, Pisa, Italy.
AD  - Unit of Periodontology, Endodontology and Restorative dentistry, Department of 
      Medical Biotechnologies, University of Siena, Siena, Italy.
FAU - Peric, Marina
AU  - Peric M
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University 
      Hospital of Pisa, Pisa, Italy.
FAU - Ghiadoni, Lorenzo
AU  - Ghiadoni L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Marhl, Urska
AU  - Marhl U
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University 
      Hospital of Pisa, Pisa, Italy.
FAU - Petrini, Morena
AU  - Petrini M
AD  - Department of Surgical, Medical and Molecular Pathology and Critical Care 
      Medicine, University of Pisa, Pisa, Italy.
AD  - Department of Medical, Oral and Biotechnological Science, University of Chieti, 
      Chieti, Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT03087266
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230122
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Glycated Hemoglobin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Humans
MH  - Acute-Phase Reaction
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glycated Hemoglobin
MH  - Follow-Up Studies
MH  - Mouth
MH  - Root Planing
MH  - Dental Scaling
MH  - C-Reactive Protein
MH  - *Chronic Periodontitis/complications/therapy
OTO - NOTNLM
OT  - C-reactive protein
OT  - acute inflammation
OT  - diabetes
OT  - periodontitis
EDAT- 2022/12/16 06:00
MHDA- 2023/03/22 06:00
CRDT- 2022/12/15 00:53
PHST- 2022/11/17 00:00 [revised]
PHST- 2022/02/23 00:00 [received]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2022/12/15 00:53 [entrez]
AID - 10.1111/jcpe.13760 [doi]
PST - ppublish
SO  - J Clin Periodontol. 2023 Apr;50(4):487-499. doi: 10.1111/jcpe.13760. Epub 2023 
      Jan 22.