PMID- 36519123
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 9
IP  - 12
DP  - 2022 Dec
TI  - Intravenous Cyclophosphamide Therapy for Anti-IFN-gamma Autoantibody-Associated 
      Talaromyces marneffei Infection.
PG  - ofac612
LID - 10.1093/ofid/ofac612 [doi]
LID - ofac612
AB  - High titers of anti-interferon-gamma autoantibodies (AIGAs) are an important factor 
      leading to persistent, relapsed, and refractory infections in HIV-negative hosts 
      infected with Talaromyces marneffei (TM). We report 5 patients treated with 
      pulses of high-dose intravenous cyclophosphamide (IVCY) who were followed for 2 
      years. Before IVCY therapy, all patients had multiple relapses, with a median 
      (interquartile range [IQR]) of 2 (1-3) instances of relapse. The median serum 
      AIGA titers (IQR) were 58 753 (41 203-89 605) ng/mL at diagnosis, 48 189.4 (15 
      537-83 375) ng/mL before IVCY therapy, and 10 721.2 (5637-13 245) ng/mL at the 
      end of IVCY therapy (P < .05). After 3 months of follow-up, the median AIGA 
      titers (IQR) rose gradually to 21 232.6 (9896-45 626) ng/mL, and to 37 464.2 (19 
      872-58 321) ng/mL at 24 months (P < .05). Five patients discontinued 
      antimicrobial therapy within 3-12 months after completion of IVCY therapy, but 
      only 1 patient had a relapse. In conclusion, pulses of short-term and high-dose 
      IVCY can effectively reduce AIGA titers.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Zeng, Wen
AU  - Zeng W
AD  - Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, 
      Sun Yat-Sen University, Shenzhen, Guangdong, China.
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Tang, Mengxin
AU  - Tang M
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Yang, Meiling
AU  - Yang M
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Fang, Gaoneng
AU  - Fang G
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Tang, Shudan
AU  - Tang S
AD  - Department of Respiratory and Critical Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Zhang, Jianquan
AU  - Zhang J
AD  - Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, 
      Sun Yat-Sen University, Shenzhen, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20221111
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC9745774
OTO - NOTNLM
OT  - Talaromyces marneffei
OT  - anti-IFN-gamma autoantibodies
OT  - intravenous cyclophosphamide therapy
COIS- Potential conflicts of interest. All authors: no reported conflicts. All authors 
      have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. 
      Conflicts that the editors consider relevant to the content of the manuscript 
      have been disclosed.
EDAT- 2022/12/16 06:00
MHDA- 2022/12/16 06:01
PMCR- 2022/11/11
CRDT- 2022/12/15 02:37
PHST- 2022/05/09 00:00 [received]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2022/12/15 02:37 [entrez]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2022/12/16 06:01 [medline]
PHST- 2022/11/11 00:00 [pmc-release]
AID - ofac612 [pii]
AID - 10.1093/ofid/ofac612 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2022 Nov 11;9(12):ofac612. doi: 10.1093/ofid/ofac612. 
      eCollection 2022 Dec.