PMID- 36519654
OWN - NLM
STAT- MEDLINE
DCOM- 20230103
LR  - 20230103
IS  - 2299-8306 (Electronic)
IS  - 0423-104X (Linking)
VI  - 73
IP  - 6
DP  - 2022
TI  - Serum IL-38 levels in patients with type 2 diabetes mellitus.
PG  - 988-989
LID - 10.5603/EP.a2022.0089 [doi]
AB  - INTRODUCTION: Interleukin 38 (IL-38) is a new member of the IL-1 family, and it 
      has anti-inflammatory activity. However, its role in type 2 diabetes mellitus 
      (T2DM) has not been reported. MATERIAL AND METHODS: The study included 40 T2DM 
      patients and 42 healthy control subjects. The anthropometric and biochemical 
      measurements were performed using an automatic biochemical analyser, 
      high-performance liquid chromatography, and electrochemiluminescence immunoassay. 
      Circulating IL-38 levels were determined by enzyme-linked immunosorbent assay. 
      RESULTS: Serum IL-38 levels in T2DM patients were significantly lower than those 
      in controls. Correlation analysis showed that serum IL-38 was negatively 
      correlated with systolic blood pressure and interleukin 17 (IL-17). CONCLUSIONS: 
      The results suggest that IL-38 may be a new biomarker of T2DM.
FAU - Zhao, Tingqi
AU  - Zhao T
AD  - Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
FAU - Yu, Mengxi
AU  - Yu M
AD  - Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
FAU - Li, Mingcai
AU  - Li M
AUID- ORCID: 0000-0003-3910-6964
AD  - Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China. limingcai@nbu.edu.cn.
AD  - Department of Immunology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 
      University School of Medicine, Ningbo, China. limingcai@nbu.edu.cn.
FAU - Li, Yan
AU  - Li Y
AUID- ORCID: 0000-0002-6763-0096
AD  - Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo 
      University, Ningbo, China.
AD  - Department of Immunology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 
      University School of Medicine, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20221215
PL  - Poland
TA  - Endokrynol Pol
JT  - Endokrynologia Polska
JID - 0370674
RN  - 0 (Biomarkers)
RN  - 0 (IL-38 protein, human)
RN  - 0 (Interleukins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Biomarkers
MH  - Interleukins
OTO - NOTNLM
OT  - interleukin 17
OT  - interleukin 38
OT  - type 2 diabetes mellitus
EDAT- 2022/12/16 06:00
MHDA- 2023/01/04 06:00
CRDT- 2022/12/15 07:02
PHST- 2022/04/02 00:00 [received]
PHST- 2022/07/07 00:00 [accepted]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2023/01/04 06:00 [medline]
PHST- 2022/12/15 07:02 [entrez]
AID - VM/OJS/J/89403 [pii]
AID - 10.5603/EP.a2022.0089 [doi]
PST - ppublish
SO  - Endokrynol Pol. 2022;73(6):988-989. doi: 10.5603/EP.a2022.0089. Epub 2022 Dec 15.