PMID- 36520013
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230210
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 6
IP  - 1
DP  - 2023 Jan 16
TI  - Emerging Strategies of Engineering and Tracking Dendritic Cells for Cancer 
      Immunotherapy.
PG  - 24-43
LID - 10.1021/acsabm.2c00790 [doi]
AB  - Dendritic cells (DCs), a kind of specialized immune cells, play key roles in 
      antitumor immune response and promotion of innate and adaptive immune responses. 
      Recently, many strategies have been developed to utilize DCs in cancer therapy, 
      such as delivering antigens and adjuvants to DCs and using scaffold to recruit 
      and activate DCs. Here we outline how different DC subsets influence antitumor 
      immunity, summarize the FDA-approved vaccines and cancer vaccines under clinical 
      trials, discuss the strategies for engineering DCs and noninvasive tracking of 
      DCs to improve antitumor immunotherapy, and reveal the potential of artificial 
      neural networks for the design of DC based vaccines.
FAU - Gao, Yu
AU  - Gao Y
AUID- ORCID: 0000-0002-8724-7748
AD  - State Key Laboratory for Organic Electronics and Information Displays & Jiangsu 
      Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu 
      National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing 
      University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, 
      China.
FAU - Wang, Zhixuan
AU  - Wang Z
AD  - School of Geography and Biological Information, Nanjing University of Posts and 
      Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
FAU - Cui, Ying
AU  - Cui Y
AD  - School of Geography and Biological Information, Nanjing University of Posts and 
      Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
FAU - Xu, Miaomiao
AU  - Xu M
AD  - School of Geography and Biological Information, Nanjing University of Posts and 
      Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
FAU - Weng, Lixing
AU  - Weng L
AUID- ORCID: 0000-0002-7719-892X
AD  - State Key Laboratory for Organic Electronics and Information Displays & Jiangsu 
      Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu 
      National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing 
      University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, 
      China.
AD  - School of Geography and Biological Information, Nanjing University of Posts and 
      Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20221215
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 0 (Cancer Vaccines)
RN  - 0 (Adjuvants, Immunologic)
SB  - IM
MH  - Humans
MH  - Dendritic Cells
MH  - Immunotherapy
MH  - *Cancer Vaccines/therapeutic use
MH  - Adjuvants, Immunologic
MH  - *Neoplasms/drug therapy
OTO - NOTNLM
OT  - cancer immunotherapy
OT  - cancer vaccine
OT  - cell tracking
OT  - dendritic cells
OT  - noninvasive imaging
EDAT- 2022/12/16 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/15 09:44
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/15 09:44 [entrez]
AID - 10.1021/acsabm.2c00790 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2023 Jan 16;6(1):24-43. doi: 10.1021/acsabm.2c00790. Epub 
      2022 Dec 15.