PMID- 36520404
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20230610
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Print)
IS  - 1933-7191 (Linking)
VI  - 30
IP  - 6
DP  - 2023 Jun
TI  - Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and 
      Improves the Fertility of Aged Female Mice.
PG  - 1834-1840
LID - 10.1007/s43032-022-01082-y [doi]
AB  - The age-related decay in oocyte quality contributes to the gradual decline in 
      fertility and the final occurrence of natural sterility. In this study, we aimed 
      to investigate the effects of the hyperbaric oxygen treatment (HBOT) on oocyte 
      quality in aging mouse oocyte. Eight- and forty-week-old female C57BL/6 J mice 
      were treated with HBO for 10 days, and the quality of oocytes was analyzed. The 
      results revealed that HBOT improved the age-related serum AMH levels. While 
      compared with untreated aged mice, HBOT showed reduced follicular apoptosis and 
      improved oocyte maturation, fertilization, and blastocyst formation in aged mice. 
      HBO triggered changes in the microRNA expression in the ovaries of aged mice. In 
      this study, 27 DEGs were identified in the HBOT mouse ovarian tissues, of which 9 
      were upregulated and 18 were downregulated. Notably, KEGG analysis revealed that 
      these genes involved in different biological processes differed significantly in 
      the ovary. Among these, the PI3K-Akt signaling was the most prominent pathway 
      that controlled the recruitment and growth of primordial follicles. The calcium 
      signaling pathway was found to be involved during the peri-implantation period. 
      These results suggest that HBOT can be applied to improve the quality of oocytes, 
      and it could be a potential clinical application to improve the fertility of aged 
      female.
CI  - (c) 2022. The Author(s), under exclusive licence to Society for Reproductive 
      Investigation.
FAU - Ma, Yang
AU  - Ma Y
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China.
FAU - Zhong, Yanyu
AU  - Zhong Y
AD  - Department of Reproductive Center, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu, China.
FAU - Chen, Xia
AU  - Chen X
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China.
FAU - Liu, Huijun
AU  - Liu H
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China.
FAU - Shi, Yichao
AU  - Shi Y
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China.
FAU - Zhang, Xiuwen
AU  - Zhang X
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China.
FAU - Sun, Huiting
AU  - Sun H
AUID- ORCID: 0000-0001-5018-5769
AD  - Department of Reproductive Center, The Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, No. 68 Gehu Road, Changzhou, 213003, 
      Jiangsu, China. 94sunhuiting@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221215
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - S88TT14065 (Oxygen)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Animals
MH  - Female
MH  - Mice
MH  - *Hyperbaric Oxygenation
MH  - Oxygen
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Mice, Inbred C57BL
MH  - Oocytes/metabolism
MH  - Fertility
PMC - PMC9753892
OTO - NOTNLM
OT  - Aged
OT  - Female Mice
OT  - Hyperbaric oxygen
OT  - MicroRNA
OT  - Ovarian reserve
COIS- The authors declare no competing interests.
EDAT- 2022/12/16 06:00
MHDA- 2023/06/01 06:42
PMCR- 2022/12/15
CRDT- 2022/12/15 11:21
PHST- 2022/05/24 00:00 [received]
PHST- 2022/09/08 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2022/12/15 11:21 [entrez]
PHST- 2022/12/15 00:00 [pmc-release]
AID - 10.1007/s43032-022-01082-y [pii]
AID - 1082 [pii]
AID - 10.1007/s43032-022-01082-y [doi]
PST - ppublish
SO  - Reprod Sci. 2023 Jun;30(6):1834-1840. doi: 10.1007/s43032-022-01082-y. Epub 2022 
      Dec 15.