PMID- 36521046
OWN - NLM
STAT- MEDLINE
DCOM- 20221219
LR  - 20221221
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 62
IP  - 11
DP  - 2022 Nov 30
TI  - Associations of adipokines and metabolic hormones with low-density lipoprotein 
      hypercholesterolemia in men and women under 45 years of age.
PG  - 63-70
LID - 10.18087/cardio.2022.11.n2239 [doi]
AB  - Aim    To study the adipokine profile in young people with hypercholesterolemia 
      and low-density lipoproteins (LDL) and to evaluate the relationship between 
      concentrations of LDL cholesterol (LDL-C) and metabolic hormones in men and women 
      younger than 45 years. Material and methods    This study included 304 subjects 
      (group 1, 56 men with LDL-C concentration <2.1 mmol/l; group 2, 87 men with 
      LDL-C concentration >/=4.2 mmol/l; group 3, 90 women with LDL-C concentration 
      <2.1 mmol/l; and group 4, 71 women with LDL-C concentration >/=4.2 mmol/l). 
      Serum concentrations of total cholesterol (C), triglycerides (TG), high-density 
      lipoprotein C, and glucose were measured by an enzymatic assay with ThermoFisher 
      Scientific kits and a KonelabPrime 30i biochemical analyzer. LDL-C was calculated 
      using the Friedewald's formula. Concentrations of amylin, C-peptide, ghrelin, 
      glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 (GLP-1), 
      glucagon, interleukin 6, insulin, leptin, monocyte chemotactic protein 1 (MCP-1), 
      pancreatic polypeptide (PP), peptide YY (PYY), tumor necrosis factor alpha 
      (TNF-alpha), adiponectin, adipsin, lipocalin-2, plasminogen activator inhibitor 1 
      (PAI-1), and resistin were measured by multiplex analysis (Human Metabolic 
      Hormone V3 and Human Adipokine Panel 1 panels).Results    The groups differed in 
      traditional cardiometabolic risk factors. In the male and female patient groups 
      with LDL-C >/=4.2 mmol/l, the prevalence of impaired fasting glucose, incidence of 
      insulin resistance, TG, and TC were higher than in subjects with LDL-C <2.1 
      mmol/l. The odds for the presence of LDL hypercholesterolemia (LDL-C >/=4.2 mmol/l) 
      were significantly associated with increased concentrations of C-peptide and 
      lipocalin-2 in men and with increased concentrations of lipocalin-2 and decreased 
      concentrations of GLP-1 in women (small er, Cyrillic<0.05).Conclusion    Increased 
      concentrations of LDL-C in young people were associated with changes in the 
      adipokine profile and with the presence of metabolic syndrome components. These 
      results were confirmed by changes in blood concentrations of metabolic markers 
      that characterize disorders of metabolic processes.
FAU - Kashtanova, capital IE, Cyrillic V
AU  - Kashtanova capital IE, CyrillicV
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Polonskaya, Ysmall a, Cyrillic V
AU  - Polonskaya YV
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Shramko, V S
AU  - Shramko VS
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Shcherbakova, L V
AU  - Shcherbakova LV
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Stakhneva, capital IE, Cyrillic capital EM, Cyrillic
AU  - Stakhneva capital IE, Cyrilliccapital EM, Cyrillic
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Sadovski, E V
AU  - Sadovski EV
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Spiridonov, A N
AU  - Spiridonov AN
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
FAU - Ragino, Yu I
AU  - Ragino YI
AD  - Research Institute of Therapy and Preventive Medicine, Affiliation of the Federal 
      Research Center Institute of Cytology and Genetics.
LA  - rus
LA  - eng
PT  - Journal Article
DEP - 20221130
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipocalin-2)
RN  - 0 (Adipokines)
RN  - 0 (C-Peptide)
RN  - 0 (Triglycerides)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Female
MH  - Male
MH  - Humans
MH  - Adolescent
MH  - Cholesterol, LDL
MH  - *Hypercholesterolemia/complications
MH  - Lipocalin-2
MH  - Adipokines
MH  - C-Peptide
MH  - Triglycerides
MH  - *Hyperlipidemias
MH  - Glucagon-Like Peptide 1
MH  - Glucose
EDAT- 2022/12/16 06:00
MHDA- 2022/12/20 06:00
CRDT- 2022/12/15 15:22
PHST- 2022/07/08 00:00 [received]
PHST- 2022/08/26 00:00 [accepted]
PHST- 2022/12/15 15:22 [entrez]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2022/12/20 06:00 [medline]
AID - 10.18087/cardio.2022.11.n2239 [doi]
PST - epublish
SO  - Kardiologiia. 2022 Nov 30;62(11):63-70. doi: 10.18087/cardio.2022.11.n2239.