PMID- 36522588
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20230403
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 117
IP  - 4
DP  - 2023 Apr
TI  - The characteristics and long-term outcomes of acute promyelocytic leukemia 
      patients with early intracranial hemorrhage.
PG  - 538-543
LID - 10.1007/s12185-022-03515-5 [doi]
AB  - Intracranial hemorrhage (ICH) is a major cause of early death (ED) and leads to 
      poor prognosis in acute promyelocytic leukemia (APL). We retrospectively 
      described 27 unselected APL patients who experienced early ICH. The ED rate was 
      37%. The 3-year overall survival (OS) rate was 45.4%, while the 3-year OS rate of 
      patients who survived through induction therapy was 87.5%. No patient experienced 
      central nervous system leukemia (CNSL). Concurrent differentiation syndrome, 
      white blood cell count, prothrombin time and D-dimer were related to death. 
      Although the ED rate among APL patients with early ICH was high, patients with 
      early ICH had a favorable outcome after surviving through induction therapy. CNSL 
      was rare despite a history of ICH during induction therapy. Compared with APL 
      patients without ICH, it seems unnecessary to administer additional measures to 
      prevent CNSL for this subpopulation in the era of all-trans retinoic acid and 
      arsenic trioxide, but this needs further validation in prospective trials.
CI  - (c) 2022. Japanese Society of Hematology.
FAU - Li, He
AU  - Li H
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Niu, Ting
AU  - Niu T
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Huang, Jie
AU  - Huang J
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Xie, Liping
AU  - Xie L
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - He, Chuan
AU  - He C
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Li, Jianjun
AU  - Li J
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Xiang, Bing
AU  - Xiang B
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Cui, Xu
AU  - Cui X
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Wu, Yu
AU  - Wu Y
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Tang, Yun
AU  - Tang Y
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Jia, Yongqian
AU  - Jia Y
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Liu, Zhigang
AU  - Liu Z
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China.
FAU - Ma, Hongbing
AU  - Ma H
AUID- ORCID: 0000-0002-1174-4078
AD  - Department of Hematology, Institute of Hematology, West China Hospital of Sichuan 
      University, #37 Guo Xue Xiang Street, Chengdu, 610041, Sichuan, China. 
      hongbingma@foxmail.com.
LA  - eng
GR  - 2022HXFH040/1.3.5 project for disciplines of excellence-Clinical Research 
      Incubation Project, West China Hospital, Sichuan University/
PT  - Journal Article
DEP - 20221215
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - S7V92P67HO (Arsenic Trioxide)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Humans
MH  - *Leukemia, Promyelocytic, Acute/complications/drug therapy
MH  - Retrospective Studies
MH  - Prospective Studies
MH  - Arsenic Trioxide/adverse effects
MH  - Tretinoin/therapeutic use
MH  - Intracranial Hemorrhages/etiology
MH  - Antineoplastic Combined Chemotherapy Protocols
OTO - NOTNLM
OT  - Acute promyelocytic leukemia
OT  - Central nervous system leukemia
OT  - Differentiation syndrome
OT  - Early death
OT  - Intracranial hemorrhage
EDAT- 2022/12/16 06:00
MHDA- 2023/04/03 06:42
CRDT- 2022/12/15 23:40
PHST- 2022/09/14 00:00 [received]
PHST- 2022/12/08 00:00 [accepted]
PHST- 2022/12/07 00:00 [revised]
PHST- 2023/04/03 06:42 [medline]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2022/12/15 23:40 [entrez]
AID - 10.1007/s12185-022-03515-5 [pii]
AID - 10.1007/s12185-022-03515-5 [doi]
PST - ppublish
SO  - Int J Hematol. 2023 Apr;117(4):538-543. doi: 10.1007/s12185-022-03515-5. Epub 
      2022 Dec 15.