PMID- 36522620
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230128
IS  - 1555-8932 (Print)
IS  - 1865-3499 (Electronic)
IS  - 1555-8932 (Linking)
VI  - 17
IP  - 1
DP  - 2022 Dec 15
TI  - Effect of green cardamom on the expression of genes implicated in obesity and 
      diabetes among obese women with polycystic ovary syndrome: a double blind 
      randomized controlled trial.
PG  - 17
LID - 10.1186/s12263-022-00719-6 [doi]
LID - 17
AB  - BACKGROUND: Polycystic ovary syndrome (PCOS) is an endocrine disease in which 
      related to obesity, metabolic disorders and is considered as one of the main 
      causes of infertility in women. This trial was investigated the effects of green 
      cardamom on the expression of genes implicated in obesity and diabetes among 
      obese women with PCOS. METHODS: One hundred ninety-four PCOS women were randomly 
      divided two groups: intervention (n = 99; 3 g/day green cardamom) and control 
      groups (n = 95). All of them were given low calorie diet. Anthropometric, 
      glycemic and androgen hormones were assessed before and after 16-week 
      intervention. The reverse transcription-polymerase chain reaction (RT-PCR) method 
      was used to measure fat mass and obesity-associated (FTO), peroxisome 
      proliferative activating receptor- (PPAR-), carnitine palmitoyltransferase 1A 
      (CPT1A), acetyl-CoA carboxylase beta (ACAB), leptin receptor (LEPR), ghrelin, and 
      lamin A/C (LAMIN) genes expression in each group. RESULTS: Anthropometric indices 
      were significantly decreased after intervention in both two studied groups. 
      Glycemic indices and androgen hormones were significantly improved in the 
      intervention group compared to the control group. The expression levels of FTO, 
      CPT1A, LEPR, and LAMIN were significantly downregulated compared to control group 
      (P < 0.001), as well as, PPAR-y was significantly upregulated in the intervention 
      group after intervention with green cardamom compared to control group 
      (P < 0.001). CONCLUSION: This current study showed that the administration of 
      green cardamom is a beneficial approach for improving anthropometric, glycemic, 
      and androgen hormones, as well as obesity and diabetes genes expression in PCOS 
      women under the low-calorie diet. TRIAL REGISTRATION: This trial was registered 
      with the Iranian Clinical Trials Registry (registration number: 
      IRCT20200608047697N1). 1 August, 2020; https://www.irct.ir/trial/48748.
CI  - (c) 2022. The Author(s).
FAU - Cheshmeh, Sahar
AU  - Cheshmeh S
AD  - Molecular and Experimental Nutritional Medicine Department, University of 
      Potsdam, Nuthetal, Germany.
FAU - Elahi, Negin
AU  - Elahi N
AD  - Student Research Committee, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
AD  - Department of Nutrition Sciences, School of Nutritional Sciences and Food 
      Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Ghayyem, Maysa
AU  - Ghayyem M
AD  - Department of Internal Medicine, Factually of Medicine, Tehran Medical Sciences, 
      Islamic Azad University of Medical Sciences, Tehran, Iran.
FAU - Mosaieby, Elaheh
AU  - Mosaieby E
AD  - Department of Pathology, Charles University, Faculty of Medicine in Pilsen, 
      Pilsen, Czech Republic.
FAU - Moradi, Shima
AU  - Moradi S
AUID- ORCID: 0000-0002-6507-7928
AD  - Student Research Committee, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran. Shima.moradi@kums.ac.ir.
AD  - Department of Nutrition Sciences, School of Nutritional Sciences and Food 
      Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. 
      Shima.moradi@kums.ac.ir.
FAU - Pasdar, Yahya
AU  - Pasdar Y
AD  - Department of Nutritional Sciences, Research Center for Environmental 
      Determinants of Health (RCEDH), Health Institute, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran.
FAU - Tahmasebi, Susan
AU  - Tahmasebi S
AD  - Department of Biochemistry, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Moradinazar, Mehdi
AU  - Moradinazar M
AD  - Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and 
      Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran.
LA  - eng
GR  - 990412/Deputy for Research and Technology, Kermanshah University of Medical 
      Sciences/
PT  - Journal Article
DEP - 20221215
PL  - Germany
TA  - Genes Nutr
JT  - Genes & nutrition
JID - 101280108
EIN - Genes Nutr. 2023 Jan 27;18(1):1. PMID: 36707760
PMC - PMC9753872
OTO - NOTNLM
OT  - Diabetes genes
OT  - Green cardamom
OT  - Obesity genes
OT  - Polycystic ovary syndrome
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/16 06:00
MHDA- 2022/12/16 06:01
PMCR- 2022/12/15
CRDT- 2022/12/15 23:41
PHST- 2021/01/26 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/12/15 23:41 [entrez]
PHST- 2022/12/16 06:00 [pubmed]
PHST- 2022/12/16 06:01 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - 10.1186/s12263-022-00719-6 [pii]
AID - 719 [pii]
AID - 10.1186/s12263-022-00719-6 [doi]
PST - epublish
SO  - Genes Nutr. 2022 Dec 15;17(1):17. doi: 10.1186/s12263-022-00719-6.