PMID- 36523225
OWN - NLM
STAT- MEDLINE
DCOM- 20221219
LR  - 20221222
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 12
IP  - 12
DP  - 2022 Dec 13
TI  - External validation of the risk prediction model for early diabetic kidney 
      disease in Taiwan population: a retrospective cohort study.
PG  - e059139
LID - 10.1136/bmjopen-2021-059139 [doi]
LID - e059139
AB  - OBJECTIVES: This study aims to independently and externally validate the Risk 
      Prediction Model for Diabetic Kidney Disease (RPM-DKD) in patients with type 2 
      diabetes mellitus (T2DM). DESIGN: This is a retrospective cohort study. SETTING: 
      Outpatient clinics at Lee's United Clinics, Taiwan, China. PARTICIPANTS: A total 
      of 2504 patients (average age 55.44 years, SD, 7.49 years) and 4455 patients 
      (average age 57.88 years, SD, 8.80 years) were included for analysis in the DKD 
      prediction and progression prediction cohorts, respectively. EXPOSURE: The 
      predicted risk for DKD and DKD progression for each patient were all calculated 
      using the RPM-DKD. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome 
      measure was overall incidence of DKD. Secondary outcomes included DKD 
      progression. The discrimination, calibration and precision of the RPM-DKD score 
      were assessed. RESULTS: The DKD prediction cohort and progression prediction 
      cohort consisted of patients with 2504 and 4455 T2DM, respectively. The RPM-DKD 
      examined in this study showed moderately discriminative ability with area under 
      the curve ranged from 0.636 to 0.681 for the occurrence of DKD and 0.620 to 0.654 
      for the progression of DKD. The Hosmer-Lemeshow chi(2) test indicted the RPM-DKD 
      was not well calibrated for predicting the occurrence of DKD and overestimated 
      the progression of DKD. The precision for predicting the occurrence and 
      progression of DKD were 43.2% and 42.2%, respectively. CONCLUSIONS: On external 
      validation, the RPM-DKD cannot accurately predict the risk of DKD occurrence and 
      progression in patients with T2DM.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Sun, Zhenzhen
AU  - Sun Z
AD  - Hainan Clinical Research Center for metabolic disease, The First Affiliated 
      Hospital of Hainan Medical University, Haikou, Hainan, China.
AD  - Nursing College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
FAU - Wang, Kun
AU  - Wang K
AD  - Nursing College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
FAU - Miller, Joshua D
AU  - Miller JD
AD  - Department of Medicine, Stony Brook University Renaissance School of Medicine, 
      Stony Brook, New York, USA.
FAU - Yuan, Xiaodan
AU  - Yuan X
AD  - Department of Public Health, Affiliated Hospital of Integrated Traditional 
      Chinese and Western, Nanjing, China.
FAU - Lee, Yau-Jiunn
AU  - Lee YJ
AD  - Department of Endocrinology, Lee's Clinic, Taiwan, China.
FAU - Lou, Qingqing
AU  - Lou Q
AUID- ORCID: 0000-0002-4743-0900
AD  - Hainan Clinical Research Center for metabolic disease, The First Affiliated 
      Hospital of Hainan Medical University, Haikou, Hainan, China 2444890144@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221213
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - *Diabetic Nephropathies/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Retrospective Studies
MH  - Taiwan/epidemiology
MH  - Risk Factors
PMC - PMC9748925
OTO - NOTNLM
OT  - DIABETES & ENDOCRINOLOGY
OT  - Diabetic nephropathy & vascular disease
OT  - General diabetes
COIS- Competing interests: None declared.
EDAT- 2022/12/17 06:00
MHDA- 2022/12/20 06:00
PMCR- 2022/12/13
CRDT- 2022/12/16 02:03
PHST- 2022/12/16 02:03 [entrez]
PHST- 2022/12/17 06:00 [pubmed]
PHST- 2022/12/20 06:00 [medline]
PHST- 2022/12/13 00:00 [pmc-release]
AID - bmjopen-2021-059139 [pii]
AID - 10.1136/bmjopen-2021-059139 [doi]
PST - epublish
SO  - BMJ Open. 2022 Dec 13;12(12):e059139. doi: 10.1136/bmjopen-2021-059139.