PMID- 36526016
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20230816
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Print)
IS  - 0168-1702 (Linking)
VI  - 324
DP  - 2023 Jan 15
TI  - A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2.
PG  - 199024
LID - S0168-1702(22)00353-7 [pii]
LID - 10.1016/j.virusres.2022.199024 [doi]
LID - 199024
AB  - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains in 
      a global pandemic, and no eradicative therapy is currently available. Host T 
      cells have been shown to play a crucial role in the antiviral immune protection 
      and pathology in Coronavirus disease 2019 (COVID-19) patients; thus, identifying 
      sufficient T-cell epitopes from the SARS-CoV-2 proteome can contribute greatly to 
      the development of T-cell epitope vaccines and the precise evaluation of host 
      SARS-CoV-2-specific cellular immunity. This review presents a comprehensive map 
      of T-cell epitopes functionally validated from SARS-CoV-2 antigens, the human 
      leukocyte antigen (HLA) supertypes to present these epitopes, and the strategies 
      to screen and identify T-cell epitopes. To the best of our knowledge, a total of 
      1349 CD8(+) T-cell epitopes and 790 CD4(+) T-cell epitopes have been defined by 
      functional experiments thus far, but most are presented by approximately twenty 
      common HLA supertypes, such as HLA-A0201, A2402, B0702, DR15, DR7 and DR11 
      molecules, and 74-80% of the T-cell epitopes are derived from S protein and 
      nonstructural protein. These data provide useful insight into the development of 
      vaccines and specific T-cell detection systems. However, the currently defined 
      T-cell epitope repertoire cannot cover the HLA polymorphism of major populations 
      in an indicated geographic region. More research is needed to depict an overall 
      landscape of T-cell epitopes, which covers the overall SARS-CoV-2 proteome and 
      global patients.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Jin, Xiaoxiao
AU  - Jin X
AD  - Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China 225002; Department 
      of Microbiology and Immunology, Medical School of Southeast University, Nanjing, 
      Jiangsu, China 210009.
FAU - Liu, Xiaotao
AU  - Liu X
AD  - Department of Microbiology and Immunology, Medical School of Southeast 
      University, Nanjing, Jiangsu, China 210009.
FAU - Shen, Chuanlai
AU  - Shen C
AD  - Department of Microbiology and Immunology, Medical School of Southeast 
      University, Nanjing, Jiangsu, China 210009. Electronic address: 
      chuanlaishen@seu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20221213
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA Antigens)
RN  - 0 (Proteome)
RN  - 0 (Spike Glycoprotein, Coronavirus)
RN  - 0 (spike protein, SARS-CoV-2)
SB  - IM
MH  - Humans
MH  - CD8-Positive T-Lymphocytes
MH  - *COVID-19
MH  - Epitopes, T-Lymphocyte/genetics
MH  - Histocompatibility Antigens Class I
MH  - HLA Antigens/genetics
MH  - Proteome
MH  - *SARS-CoV-2/genetics
MH  - Spike Glycoprotein, Coronavirus
PMC - PMC9757803
OTO - NOTNLM
OT  - HLA restriction
OT  - SARS-CoV-2
OT  - T-cell epitope
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/17 06:00
MHDA- 2023/01/28 06:00
PMCR- 2022/12/13
CRDT- 2022/12/16 19:24
PHST- 2022/11/02 00:00 [received]
PHST- 2022/12/10 00:00 [revised]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2022/12/17 06:00 [pubmed]
PHST- 2023/01/28 06:00 [medline]
PHST- 2022/12/16 19:24 [entrez]
PHST- 2022/12/13 00:00 [pmc-release]
AID - S0168-1702(22)00353-7 [pii]
AID - 199024 [pii]
AID - 10.1016/j.virusres.2022.199024 [doi]
PST - ppublish
SO  - Virus Res. 2023 Jan 15;324:199024. doi: 10.1016/j.virusres.2022.199024. Epub 2022 
      Dec 13.