PMID- 36526194 OWN - NLM STAT- MEDLINE DCOM- 20230130 LR - 20230130 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 863 DP - 2023 Mar 10 TI - Independent and combined associations of urinary arsenic exposure and serum sex steroid hormones among 6-19-year old children and adolescents in NHANES 2013-2016. PG - 160883 LID - S0048-9697(22)07986-4 [pii] LID - 10.1016/j.scitotenv.2022.160883 [doi] AB - Arsenic exposure may disrupt sex steroid hormones, causing endocrine disruption. However, human evidence is limited and inconsistent, especially for children and adolescents. To evaluate the independent and combined associations between arsenic exposure and serum sex steroid hormones in children and adolescents, we conducted a cross-sectional analysis of data from 1063 participants aged 6 to 19 years from the 2013-2016 National Health and Nutrition Examination Survey (NHANES). Three urine arsenic metabolites were examined, as well as three serum sex steroid hormones, estradiol (E(2)), total testosterone (TT), and sex hormone-binding globulin (SHBG). The ratio of TT to E(2) (TT/E(2)) and the free androgen index (FAI) generated by TT/SHBG were also assessed. Linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were used to evaluate the associations of individual or arsenic metabolite combinations with sex steroid hormones by gender and age stratification. Positive associations were found between total arsenic and arsenic metabolites with TT, E(2), and FAI. In contrast, negative associations were found between arsenic metabolites and SHBG. Furthermore, there was an interaction after gender-age stratification between DMA and SHBG in female adolescents. Notably, based on the WQS and BKMR model results, the combined association of arsenic and its metabolites was positively associated with TT, E(2), and FAI and negatively associated with SHBG. Moreover, DMA and MMA dominated the highest weights among the arsenic metabolites. Overall, our results indicate that exposure to arsenic, either alone or in mixtures, may alter sex steroid hormone levels in children and adolescents. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Zhang, Yuanli AU - Zhang Y AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Xing, Hengrui AU - Xing H AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Hu, Zeyu AU - Hu Z AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Xu, Wanjing AU - Xu W AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Tang, Yanling AU - Tang Y AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Zhang, Jingjing AU - Zhang J AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. FAU - Niu, Qiang AU - Niu Q AD - Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. Electronic address: niuqiang@shzu.edu.cn. LA - eng PT - Journal Article DEP - 20221213 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - N712M78A8G (Arsenic) RN - 4TI98Z838E (Estradiol) RN - 0 (Gonadal Steroid Hormones) RN - 0 (Sex Hormone-Binding Globulin) RN - 3XMK78S47O (Testosterone) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Young Adult MH - *Arsenic MH - Bayes Theorem MH - Cross-Sectional Studies MH - Estradiol MH - Gonadal Steroid Hormones MH - Nutrition Surveys MH - Sex Hormone-Binding Globulin/analysis MH - Testosterone OTO - NOTNLM OT - Adolescents OT - Arsenic metabolites OT - Children OT - Mixture exposure OT - Sex steroid hormones COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2022/12/17 06:00 MHDA- 2023/01/24 06:00 CRDT- 2022/12/16 19:27 PHST- 2022/07/26 00:00 [received] PHST- 2022/12/08 00:00 [revised] PHST- 2022/12/08 00:00 [accepted] PHST- 2022/12/17 06:00 [pubmed] PHST- 2023/01/24 06:00 [medline] PHST- 2022/12/16 19:27 [entrez] AID - S0048-9697(22)07986-4 [pii] AID - 10.1016/j.scitotenv.2022.160883 [doi] PST - ppublish SO - Sci Total Environ. 2023 Mar 10;863:160883. doi: 10.1016/j.scitotenv.2022.160883. Epub 2022 Dec 13.