PMID- 36527628
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230804
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1395
DP  - 2022
TI  - Effects of Exercise-Diet Therapy on Cognitive Function in Healthy Elderly People 
      Evaluated by Deep Learning Based on Basic Blood Test Data.
PG  - 139-143
LID - 10.1007/978-3-031-14190-4_24 [doi]
AB  - BACKGROUND: Recent studies reported that vascular cognitive impairment in the 
      elderly caused by arteriosclerosis plays an important role in cognitive disorders 
      in both vascular dementia and Alzheimer's disease. In addition, systemic 
      metabolic disorders such as oxygen metabolism dysfunction could be risk of 
      dementia. Based on these findings, we have developed a deep neural network-based 
      screening test (DNN-based test) of cognitive function using basic blood test 
      data, which allowed prediction of cognitive function expressed by Mini Mental 
      State Examination (MMSE) scores. AIM: Here, we investigated whether the DNN-based 
      test could be applicable to assessment of the effects of exercise-diet on 
      cognitive function. METHODS: We studied the following two groups: (1) seven 
      subjects of the local fitness gym (68.6 +/- 3.2 years old). We evaluated cognitive 
      function by the DNN-based test using blood data before and after the intervention 
      (for 3 months). These results were compared with the measured MMSE score. (2) we 
      studied a total of 230 subjects (67.9 +/- 7.4 years old) who were members of the 
      Tsuminory health class (Apple classroom). We assessed cognitive function by the 
      DNN-based test before and after the intervention (for 2 months). We compared the 
      predicted MMSE scores by the DNN-based test before and after the 2-month 
      intervention. RESULTS: In the first group, the MMSE score predicted by the 
      DNN-based test increased from 27.1 +/- 0.8 to 27.6 +/- 0.7 after the intervention 
      period (p = 0.024). The measured MMSE score also increased after exercise, but 
      not significant (P = 0.28). In the second group, the exercise-diet therapy 
      increased the predicted MMSE scores in 189 cases (p < 0.001). In contrast, the 
      therapy significantly reduced the mean MMSE score (p < 0.001). DISCUSSION: The 
      MMSE score predicted by the DNN-based test were increased by exercise-diet 
      therapy in most subjects. The DNN-based test may be useful to monitor the effect 
      of exercise-diet therapy on cognitive function aged people.
CI  - (c) 2022. Springer Nature Switzerland AG.
FAU - Sakatani, K
AU  - Sakatani K
AD  - Department of Human and Engineered Environmental Studies, Graduate School of 
      Frontier Sciences, The University of Tokyo, Tokyo, Japan. 
      k.sakatani@edu.k.u-tokyo.ac.jp.
FAU - Oyama, K
AU  - Oyama K
AD  - Department of Computer Science, College of Engineering, Nihon University, Tokyo, 
      Japan.
FAU - Hu, L
AU  - Hu L
AD  - Department of Human and Engineered Environmental Studies, Graduate School of 
      Frontier Sciences, The University of Tokyo, Tokyo, Japan.
FAU - Warisawa, S
AU  - Warisawa S
AD  - Department of Human and Engineered Environmental Studies, Graduate School of 
      Frontier Sciences, The University of Tokyo, Tokyo, Japan.
FAU - Yamashita, T
AU  - Yamashita T
AD  - Tsuminori Internal Medicine Clinic, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Aged
MH  - Humans
MH  - Middle Aged
MH  - *Dementia/diagnosis
MH  - *Deep Learning
MH  - Cognition
MH  - *Cognitive Dysfunction/diagnosis/complications
MH  - Exercise
MH  - Diet
MH  - Hematologic Tests/adverse effects
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - Deep neural network
OT  - Dementia
OT  - Mild cognitive impairment
OT  - Vascular cognitive impairment
EDAT- 2022/12/18 06:00
MHDA- 2022/12/21 06:00
CRDT- 2022/12/17 11:18
PHST- 2022/12/17 11:18 [entrez]
PHST- 2022/12/18 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
AID - 10.1007/978-3-031-14190-4_24 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2022;1395:139-143. doi: 10.1007/978-3-031-14190-4_24.