PMID- 36527750
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20230207
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 641
DP  - 2023 Jan 22
TI  - Comparison of bone ingrowth between two porous titanium alloy rods with biogenic 
      lamellar structures and diamond crystal lattice on femoral condyles in rabbits.
PG  - 155-161
LID - S0006-291X(22)01701-6 [pii]
LID - 10.1016/j.bbrc.2022.12.036 [doi]
AB  - PURPOSE: The comparison of bone ingrowth between two types of porous titanium 
      alloy rods with different micro-architectures including diamond crystal lattice 
      (Re-rod) and biogenic lamellar configurations (Bi-rod) on femoral condyles was 
      investigated in this study. METHODS: Twelve rabbits were used. Re-rod (Re-rod 
      group) and Bi-rod (Bi-rod group) were implanted randomly in femoral condyles of 
      each rabbits respectively. Bone ingrowth of these two rods were investigated and 
      compared. 4 and 12 weeks after the operation, X-ray, micro-CT and histological 
      examinations were performed. RESULTS: No femoral condyle fracture and rod 
      defluxion in the two groups was noted in the X-ray images during the observation 
      period. Micro-CT images showed that all metal trabeculae in the Bi-rod group were 
      covered by new bone at 4 and 12 weeks, whereas partial metal trabeculae in the 
      Re-rod group were still uncovered at 12 weeks. Histological images showed that 
      there was new bone growth in the centre and periphery of Bi-rods at 4 and 12 
      weeks, and there were several areas without new bone ingrowth at 4 and 12 weeks 
      in the centre of Re-rods. In micro-CT analysis, the bone volume to total volume 
      (BV/TV) of the volume of interest (VOI) of the Bi-rod group was higher than in 
      the Re-rod group [(0.0794 +/- 0.0021) % Vs (0.0521 +/- 0.0032) % and 
      (0.0875 +/- 0.0039) % Vs (0.0702 +/- 0.0028) % respectively, P < 0.05] at 4 weeks and 
      12 weeks. Whereas, the mean trabecular thickness (Tb.Th) values of VOI between 
      the two groups were not significantly statistically different at 4 and 12 weeks. 
      In histological analysis, the BV/TV of the VOI of the Bi-rod group was higher 
      than in the Re-rod group [(0.0624 +/- 0.0021) % Vs (0.0435 +/- 0.0028) % and 
      (0.0675 +/- 0.0024) % Vs (0.0476 +/- 0.0031) % respectively, P < 0.05] at 4 weeks and 
      12 weeks. CONCLUSION: These results showed that Bi-rods got better bone ingrowth 
      in femoral condyles of rabbits compared with Re-rods.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Li, Wei
AU  - Li W
AD  - Medical College, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China; 
      Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Department of Information, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Yang, Xinglan
AU  - Yang X
AD  - Clinic of Military Patients, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Xie, Qingyun
AU  - Xie Q
AD  - Medical College, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China; 
      Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China. Electronic address: xqingyun@163.com.
FAU - Wang, Cairu
AU  - Wang C
AD  - Medical College, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China; 
      Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China. Electronic address: cairuwang@126.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
PT  - Research Support, Non-U.S. Gov't
DEP - 20221212
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Alloys)
RN  - 7782-40-3 (Diamond)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Rabbits
MH  - *Alloys
MH  - Bone and Bones
MH  - Diamond/chemistry
MH  - Porosity
MH  - *Titanium/chemistry
OTO - NOTNLM
OT  - Biogenic lamellar
OT  - Diamond crystal lattice
OT  - Femoral condyle
OT  - Porous titanium alloy
OT  - Rabbit
COIS- Declaration of competing interest The authors have declared that no competing 
      interests exist.
EDAT- 2022/12/18 06:00
MHDA- 2023/01/13 06:00
CRDT- 2022/12/17 18:13
PHST- 2022/11/19 00:00 [received]
PHST- 2022/11/24 00:00 [revised]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2022/12/18 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2022/12/17 18:13 [entrez]
AID - S0006-291X(22)01701-6 [pii]
AID - 10.1016/j.bbrc.2022.12.036 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2023 Jan 22;641:155-161. doi: 
      10.1016/j.bbrc.2022.12.036. Epub 2022 Dec 12.