PMID- 36527856
OWN - NLM
STAT- MEDLINE
DCOM- 20230106
LR  - 20230111
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 224
DP  - 2023 Feb 5
TI  - Chemical profiling and quantification of Yihuang decoction by high performance 
      liquid chromatography coupled with quadrupole time-of-flight mass spectrometry 
      and a diode array detector.
PG  - 115199
LID - S0731-7085(22)00620-3 [pii]
LID - 10.1016/j.jpba.2022.115199 [doi]
AB  - Yihuang decoction (YHD) is one of the most famous formulas in tradition Chinese 
      medicine (TCM) and has been clinically used for treatment of vaginitis, pelvic 
      inflammation and other gynecological diseases for hundreds of years. However, its 
      chemical composition remains unclear. In this study, high performance liquid 
      chromatography coupled with quadrupole time-of-flight mass spectrometry 
      (HPLC-Q-TOF-MS) was employed for its chemical profiling investigation. As a 
      result, 90 components were chemically defined, including 23 alkaloids, 14 organic 
      acids, 3 phenylethanoid glycosides, 4 iridoid glycosides, 5 terpenoid lactones, 
      10 flavonoids, 8 nucleobases and nucleosides, 12 amino acids, and 11 other 
      compounds. In addition, 8 representative compounds (acteoside, allantoin, 
      berberine, 4-O-feruloylquinic acid, 5-O-feruloylquinic acid, gallic acid, 
      geniposidic acid, and phellodendrine) were simultaneously determined in 10 
      batches of YHD samples by HPLC with a diode array detector (HPLC-DAD). For all 
      the analytes, their calibration curves showed good linearity (R(2) >0.9990) 
      within the test ranges. RSDs of precision, repeatability and stability test were 
      all below 3.50%. The overall recoveries ranged from 93.63% to 105.02%, with RSDs 
      less than 3.50%. This study is supposed to exhibit a comprehensive chemical 
      profiling of YHD and to provide some strong basis for quality control and even 
      for action mechanism of this ancient classical prescription.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Zhou, Jinxin
AU  - Zhou J
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China.
FAU - Yu, Sheng
AU  - Yu S
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China.
FAU - Wang, Bingqian
AU  - Wang B
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China.
FAU - Wei, Xing
AU  - Wei X
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China.
FAU - Shan, Mingqiu
AU  - Shan M
AD  - Jiangsu Key Laboratory for High Technology Research of TCM Formula, Nanjing 
      University of Chinese Medicine, Nanjing, PR China; School of Pharmacy, Nanjing 
      University of Chinese Medicine, Nanjing, PR China. Electronic address: 
      shanmingqiu@njucm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221214
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Nucleosides)
SB  - IM
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Tandem Mass Spectrometry/methods
MH  - *Drugs, Chinese Herbal/chemistry
MH  - Medicine, Chinese Traditional
MH  - Nucleosides
OTO - NOTNLM
OT  - HPLC-DAD
OT  - HPLC-Q-TOF-MS
OT  - Qualitative analysis
OT  - Quantitative analysis
OT  - Yihuang decoction
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/18 06:00
MHDA- 2023/01/07 06:00
CRDT- 2022/12/17 18:22
PHST- 2022/11/11 00:00 [received]
PHST- 2022/12/04 00:00 [revised]
PHST- 2022/12/11 00:00 [accepted]
PHST- 2022/12/18 06:00 [pubmed]
PHST- 2023/01/07 06:00 [medline]
PHST- 2022/12/17 18:22 [entrez]
AID - S0731-7085(22)00620-3 [pii]
AID - 10.1016/j.jpba.2022.115199 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2023 Feb 5;224:115199. doi: 10.1016/j.jpba.2022.115199. Epub 
      2022 Dec 14.