PMID- 36529006
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230117
IS  - 1724-191X (Electronic)
IS  - 1120-1797 (Linking)
VI  - 105
DP  - 2023 Jan
TI  - Automation of pencil beam scanning proton treatment planning for intracranial 
      tumours.
PG  - 102503
LID - S1120-1797(22)02098-1 [pii]
LID - 10.1016/j.ejmp.2022.11.007 [doi]
AB  - PURPOSE: To evaluate the feasibility of comprehensive automation of an 
      intra-cranial proton treatment planning. MATERIALS AND METHODS: Class solution 
      (CS) beam configuration selection allows the user to identify predefined beam 
      configuration based on target localization; automatic CS (aCS) will then explore 
      all the possible CS beam geometries. Ten patients, already used for the 
      evaluation of the automatic selection of the beam configuration, have been also 
      employed to training an algorithm based on the computation of a benchmark dose 
      exploit automatic general planning solution (GPS) optimization with a wish list 
      approach for the planning optimization. An independent cohort of ten patients has 
      been then used for the evaluation step between the clinical and the GPS plan in 
      terms of dosimetric quality of plans and the time needed to generate a plan. 
      RESULTS: The definition of a beam configuration requires on average 22 min (range 
      9-29 min). The average time for GPS plan generation is 18 min (range 7-26 min). 
      Median dose differences (GPS-Manual) for each OAR constraints are: brainstem 
      -1.60 Gy, left cochlea -1.22 Gy, right cochlea -1.42 Gy, left eye 0.55 Gy, right 
      eye -2.33 Gy, optic chiasm -1.87 Gy, left optic nerve -4.45 Gy, right optic nerve 
      -2.48 Gy and optic tract -0.31 Gy. Dosimetric CS and aCS plan evaluation shows a 
      slightly worsening of the OARs values except for the optic tract and optic chiasm 
      for both CS and aCS, where better results have been observed. CONCLUSION: This 
      study has shown the feasibility and implementation of the automatic planning 
      system for intracranial tumors. The method developed in this work is ready to be 
      implemented in a clinical workflow.
CI  - Copyright (c) 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Placidi, Lorenzo
AU  - Placidi L
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. 
      Electronic address: lorenzo.placidi@policlinicogemelli.it.
FAU - Righetto, Roberto
AU  - Righetto R
AD  - Proton Therapy Department, Azienda Provinciale per i Servizi Sanitari (APSS), 
      Trento, Italy.
FAU - Vecchi, Claudio
AU  - Vecchi C
AD  - Tecnologie Avanzate Srl, Turin, Italy.
FAU - Zara, Stefania
AU  - Zara S
AD  - Tecnologie Avanzate Srl, Turin, Italy.
FAU - Alparone, Alessandro
AU  - Alparone A
AD  - Tecnologie Avanzate Srl, Turin, Italy.
FAU - Moretti, Roberto
AU  - Moretti R
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Amelio, Dante
AU  - Amelio D
AD  - Proton Therapy Department, Azienda Provinciale per i Servizi Sanitari (APSS), 
      Trento, Italy.
FAU - Scartoni, Daniele
AU  - Scartoni D
AD  - Proton Therapy Department, Azienda Provinciale per i Servizi Sanitari (APSS), 
      Trento, Italy.
FAU - Schwarz, Marco
AU  - Schwarz M
AD  - Proton Therapy Department, Azienda Provinciale per i Servizi Sanitari (APSS), 
      Trento, Italy; Radiation Oncology Department, Fred Hutchinson Cancer Center, 
      Seattle, WA, USA.
LA  - eng
PT  - Journal Article
DEP - 20221217
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
RN  - 0 (Protons)
SB  - IM
MH  - Humans
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Protons
MH  - Radiotherapy Dosage
MH  - *Radiotherapy, Intensity-Modulated/methods
MH  - *Proton Therapy/methods
MH  - *Brain Neoplasms/diagnostic imaging/radiotherapy
MH  - Organs at Risk
OTO - NOTNLM
OT  - Automatic beam selection
OT  - Automatic planning
OT  - Intracranial tumor
OT  - PBS
OT  - Proton therapy
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/19 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/18 18:20
PHST- 2022/04/26 00:00 [received]
PHST- 2022/11/04 00:00 [revised]
PHST- 2022/11/25 00:00 [accepted]
PHST- 2022/12/19 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/18 18:20 [entrez]
AID - S1120-1797(22)02098-1 [pii]
AID - 10.1016/j.ejmp.2022.11.007 [doi]
PST - ppublish
SO  - Phys Med. 2023 Jan;105:102503. doi: 10.1016/j.ejmp.2022.11.007. Epub 2022 Dec 17.