PMID- 36530824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 0971-9261 (Print)
IS  - 1998-3891 (Electronic)
IS  - 0971-9261 (Linking)
VI  - 27
IP  - 5
DP  - 2022 Sep-Oct
TI  - Correlation of Urinary Biomarkers (Interleukin-6, Transforming growth factor-beta, 
      E-Cadherin, and MCP-1) with Conventional Parameters of Disease Progression in 
      Patients of Posterior Urethral Valves: A Comparative Analysis.
PG  - 537-543
LID - 10.4103/jiaps.jiaps_182_21 [doi]
AB  - AIMS: Posterior urethral valves (PUV) are the leading cause of end-stage renal 
      disease in boys. The study aimed to look at the ongoing renal damage and 
      profibrotic activity by measuring the levels of Interleukin-6 (IL-6), 
      Transforming growth factor-beta (TGF-beta), E-cadherin, and Monocyte Chemoattractant 
      Protein-1 (MCP-1) and observing trends in subsequent follow-ups and at the same 
      time correlating them with the established parameters of disease progression. 
      MATERIALS AND METHODS: This prospective study included 36 consecutive patients of 
      PUV, managed over a period of 18 months. IL-6, TGF-beta, E-cadherin, and MCP-1 were 
      measured in urine samples at the time of admission, pre-fulguration and 3 months' 
      and 9 months' post fulguration. The observed values were correlated with the 
      conventional parameters used in clinical practice. RESULTS: All the biomarkers 
      showed statistically significant trends when these values were compared on 
      admission, postoptimization and 3 months' and 9 months' postfulguration. None of 
      the biomarkers showed a significant correlation with renal function tests. 
      E-Cadherin and TGF-beta showed a positive and a negative correlation with 
      ultrasonography (USG) kidney, ureter, and bladder (KUB) respectively. E-Cadherin 
      showed a positive correlation, whereas IL-6 and TGFbeta showed negative correlation 
      respectively with micturating cystourethrogram (MCUG). IL-6 showed statistically 
      a significant negative correlation with dimercapto succinic acid (DMSA). MCP-1 
      did not show any significant correlation with USG KUB, MCUG and DMSA. CONCLUSION: 
      This study concludes that E-Cadherin, IL-6, TGF-beta can be promising urinary 
      biomarkers for early detection of the ongoing renal damage in patients of PUV 
      following valve fulguration. MCP-1 may have more complex interactions, with 
      inflammatory markers; which warrants further research.
CI  - Copyright: (c) 2022 Journal of Indian Association of Pediatric Surgeons.
FAU - Mittal, Priyanka Garg
AU  - Mittal PG
AD  - Department of Pediatric Surgery, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Samujh, Ram
AU  - Samujh R
AD  - Department of Pediatric Surgery, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Peters, Nitin James
AU  - Peters NJ
AD  - Department of Pediatric Surgery, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Sharma, Sadhna
AU  - Sharma S
AD  - Department of Biochemistry, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20220909
PL  - India
TA  - J Indian Assoc Pediatr Surg
JT  - Journal of Indian Association of Pediatric Surgeons
JID - 101179870
PMC - PMC9757802
OTO - NOTNLM
OT  - E-cadherin
OT  - interleukin-6
OT  - monocyte chemoattractant protein-1
OT  - posterior urethral valves
OT  - transforming growth factor-beta
COIS- There are no conflicts of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/09/01
CRDT- 2022/12/19 03:37
PHST- 2021/08/31 00:00 [received]
PHST- 2021/09/07 00:00 [revised]
PHST- 2021/10/28 00:00 [accepted]
PHST- 2022/12/19 03:37 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - JIAPS-27-537 [pii]
AID - 10.4103/jiaps.jiaps_182_21 [doi]
PST - ppublish
SO  - J Indian Assoc Pediatr Surg. 2022 Sep-Oct;27(5):537-543. doi: 
      10.4103/jiaps.jiaps_182_21. Epub 2022 Sep 9.