PMID- 36531697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - The impact of extra-valvular cardiac damage on mid-term clinical outcome 
      following transcatheter aortic valve replacement in patients with severe aortic 
      stenosis.
PG  - 1039208
LID - 10.3389/fcvm.2022.1039208 [doi]
LID - 1039208
AB  - AIMS: To quantify extra-valvular cardiac damage associated with severe aortic 
      valve stenosis (AS), a novel staging model was proposed. This study aimed to 
      validate this model in patients undergoing transcatheter aortic valve replacement 
      (TAVR) as well as to assess its prognostic impact. METHODS AND RESULTS: Based on 
      echocardiographic findings, the following stages were applied: isolated AS (stage 
      0), left ventricular (LV) damage (stage 1), left atrial or mitral valve damage 
      (stage 2), pulmonary hypertension or tricuspid regurgitation (stage 3), or right 
      ventricular dysfunction (stage 4). The primary endpoint was 2-year all-cause 
      mortality. The distribution across stages was 0.8% at stage 0, 7.5% at stage 1, 
      63.3% at stage 2, 18.3% at stage 3, and 10.1% at stage 4. All-cause mortality 
      increased at all stages 1-4 (12.1%, 18.2%, 26.6%, and 28.2%; p = 0.023). In the 
      multivariate model, the stage of cardiac damage, age, New York Heart Association 
      (NYHA) class III/IV, peripheral artery disease, and previous pacemaker were 
      independent predictors of the primary endpoint. CONCLUSIONS: Patients treated for 
      severe AS show a high prevalence of extra-valvular cardiac damage. An increase in 
      stage is associated with higher 2-year all-cause mortality. The application of 
      this staging model may add value to current treatment algorithms.
CI  - Copyright (c) 2022 Pellegrini, Duesmann, Rheude, Berg, Alvarez-Covarrubias, 
      Trenkwalder, Mayr, Schurmann, Nicol, Xhepa and Joner.
FAU - Pellegrini, Costanza
AU  - Pellegrini C
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Duesmann, Charlotte
AU  - Duesmann C
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Rheude, Tobias
AU  - Rheude T
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Berg, Amelie
AU  - Berg A
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Alvarez-Covarrubias, Hector A
AU  - Alvarez-Covarrubias HA
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Trenkwalder, Teresa
AU  - Trenkwalder T
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Mayr, N Patrick
AU  - Mayr NP
AD  - Institut fur Anasthesiologie, Deutsches Herzzentrum Munchen, Technical University 
      Munich, Munich, Germany.
FAU - Schurmann, Friederike
AU  - Schurmann F
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Nicol, Philipp
AU  - Nicol P
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Xhepa, Erion
AU  - Xhepa E
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
FAU - Joner, Michael
AU  - Joner M
AD  - Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technical University Munich, Munich, Germany.
AD  - Deutsches Zentrum fur Herz- und Kreislauf-Forschung (DZHK) e.V. (German Center 
      for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20221201
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9751869
OTO - NOTNLM
OT  - aortic stenosis
OT  - cardiac damage
OT  - femoral
OT  - stages of cardiac damage
OT  - transcatheter aortic valve implantation (TAVI)
OT  - transthoracic echocardiogram
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/01/01
CRDT- 2022/12/19 03:58
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/01 00:00 [accepted]
PHST- 2022/12/19 03:58 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.1039208 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Dec 1;9:1039208. doi: 10.3389/fcvm.2022.1039208. 
      eCollection 2022.