PMID- 36531723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Median nerve stimulation elevates ventricular fibrillation threshold via the 
      cholinergic anti-inflammatory pathway in myocardial infarction canine model.
PG  - 904117
LID - 10.3389/fcvm.2022.904117 [doi]
LID - 904117
AB  - BACKGROUND: Median nerve stimulation (MNS) diminishes regional myocardial 
      ischemia and ventricular arrhythmia; however, the underlying mechanism has not 
      been elucidated. METHODS: In this study, we randomly categorized 22 adult mongrel 
      dogs into a control group, MNS group 1, and MNS group 2. After a 4-week 
      experimental myocardial infarction (MI), ventricular electrophysiology was 
      measured in the MNS group 1 before and after 30 min of MNS. The same measurements 
      were performed in the MNS group 2 dogs via bilateral vagotomy. Venous blood and 
      ventricular tissue were collected to detect molecular indicators related to 
      inflammation and cholinergic pathways by enzyme-linked immunosorbent assay 
      (ELISA), immunohistochemistry (IHC), and Western blot (WB). RESULTS: No 
      significant changes were reported in the ventricular effective refractory period 
      (ERP) in the MNS group 1 and MNS group 2 dogs before and after MNS. The 
      ventricular fibrillation threshold (VFT) in the MNS group 1 was significantly 
      higher than that in the MNS group 2 (20.3 +/- 3.7 V vs. 8.7 +/- 2.9 V, P < 0.01). The 
      levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and nuclear 
      transcription factor-kappaB (NF-kappaB) were lower (P < 0.01), whereas the levels of Ach 
      were higher in the peri-infarct zone tissues in the MNS group 1 dogs than those 
      in the MNS group 2 dogs (P < 0.01). CONCLUSION: This study demonstrated that MNS 
      increases VFT in a canine model with MI. The effects of MNS on VFT are 
      potentially associated with the cholinergic anti-inflammatory pathway.
CI  - Copyright (c) 2022 Wang, Qian, Yao, Wang, Zhang, Zhang and Zhao.
FAU - Wang, Xuewen
AU  - Wang X
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Qian, Yongsheng
AU  - Qian Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Yao, Yajun
AU  - Yao Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Wang, Youcheng
AU  - Wang Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Zhang, Youjing
AU  - Zhang Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Zhang, Shujuan
AU  - Zhang S
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
FAU - Zhao, Qingyan
AU  - Zhao Q
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
AD  - Cardiovascular Research Institute of Wuhan University, Wuhan, China.
AD  - Hubei Key Laboratory of Cardiology, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20221201
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9751050
OTO - NOTNLM
OT  - arrhythmia
OT  - cholinergic anti-inflammatory pathway
OT  - median nerve
OT  - myocardial infarction
OT  - sudden cardiac death
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/01/01
CRDT- 2022/12/19 03:58
PHST- 2022/03/25 00:00 [received]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/12/19 03:58 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.904117 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Dec 1;9:904117. doi: 10.3389/fcvm.2022.904117. 
      eCollection 2022.