PMID- 36531833
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230103
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 2022
DP  - 2022
TI  - The Characteristics of Diverticular Disease in Caribbean Population: A Control 
      Group Study.
PG  - 8360837
LID - 10.1155/2022/8360837 [doi]
LID - 8360837
AB  - BACKGROUND: Diverticulosis is not well characterized in the Caribbeans. Our aim 
      was to compare the anatomical presentation of colonic diverticulosis in African 
      Caribbeans (group AC) versus Europeans (group E) and severity. METHODS: We 
      conducted a prospective controlled study involving 274 patients admitted for 
      lower gastrointestinal haemorrhage (LGIH) in France (center 1: Guadeloupe; center 
      2: La Roche-sur-Yon); 179 cases with diverticular haemorrhage, including 129 in 
      group AC and 40 in group E. Exploration of the colon included a detailed 
      assessment of diverticula using a dedicated endoscopic grid. RESULTS: AC and E 
      had similar characteristics in terms of age, gender, previous history of LGIH, 
      body mass index, dietary habits, and medications, but AC had significantly poorer 
      hemodynamic parameters at admission and required more blood transfusions (66.7% 
      vs. 42.5%; p=0.01) during hospitalization. Out of the 169 patients included in 
      the study, a complete exploration of the colon was achieved in 81% (N = 137) (AC, 
      n = 106; E, n = 31), and revealed right-side diverticulosis in AC (in 90.6%, 
      included into a pancolonic form in 73.6% vs. 35.5%; p=0.0002) and left-side 
      diverticulosis in E (in 96.8%, isolated form in 58.1% vs. 9.4%, p=0.0002). These 
      data were confirmed by a sensitivity analysis using an endoscopic grid in 92 
      patients, achieving a higher frequency and larger size of diverticula in AC. 
      CONCLUSION: Our study has shown that diverticulosis was pancolonic in AC and more 
      frequently associated with more severe haemorrhage than the left-sided 
      diverticulosis of Europeans. This anatomical presentation may be driven by the 
      genetic background more than the environment and diet.
CI  - Copyright (c) 2022 Moana Gelu-Simeon et al.
FAU - Gelu-Simeon, Moana
AU  - Gelu-Simeon M
AUID- ORCID: 0000-0001-6212-869X
AD  - Univ Antilles, Univ Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Sante 
      Environnement et Travail), UMR-S 1085, Pointe-a-Pitre F-97100, France.
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Schnee, Matthieu
AU  - Schnee M
AUID- ORCID: 0000-0001-6152-405X
AD  - Service d'Hepato-Gastroenterologie, CHD Vendee-La Roche sur Yon, la Roche sur Yon 
      F-85000, France.
FAU - Lafrance, Marie-Josee
AU  - Lafrance MJ
AUID- ORCID: 0000-0001-8912-4883
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Plazy-Chabrand, Pauline
AU  - Plazy-Chabrand P
AUID- ORCID: 0000-0002-6458-4987
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Schneck, Anne-Sophie
AU  - Schneck AS
AUID- ORCID: 0000-0001-6781-2562
AD  - Service de Chirurgie Digestive, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Saint-Georges, Georgette
AU  - Saint-Georges G
AUID- ORCID: 0000-0003-3594-4231
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Alexis, Marceline
AU  - Alexis M
AUID- ORCID: 0000-0001-5448-3544
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
FAU - Delumeau, Stephanie
AU  - Delumeau S
AUID- ORCID: 0000-0003-2406-7990
AD  - Service de Radiologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, France.
FAU - Montigny, Philippe
AU  - Montigny P
AUID- ORCID: 0000-0001-6056-2636
AD  - Service de Radiologie, CHD Vendee-La Roche sur Yon, la Roche sur Yon F-85000, 
      France.
FAU - Faroux, Roger
AU  - Faroux R
AUID- ORCID: 0000-0003-4222-8989
AD  - Service d'Hepato-Gastroenterologie, CHD Vendee-La Roche sur Yon, la Roche sur Yon 
      F-85000, France.
FAU - Dimet, Jerome
AU  - Dimet J
AUID- ORCID: 0000-0002-9376-1583
AD  - Centre de Recherche Clinique, Centre Hospitalier Intercommunal de Mont de Marsan 
      et du Pays des Sources, Mont de Marsan F-40000, France.
FAU - Saillard, Eric
AU  - Saillard E
AUID- ORCID: 0000-0001-6877-9071
AD  - Service d'Hepato-Gastroenterologie, CHU de la Guadeloupe, Pointe-a-Pitre F-97100, 
      France.
LA  - eng
PT  - Journal Article
DEP - 20221207
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - Control Groups
MH  - Caribbean People
MH  - Risk Factors
MH  - *Diverticular Diseases/epidemiology
MH  - Gastrointestinal Hemorrhage/etiology
MH  - *Diverticulum
PMC - PMC9750784
COIS- The authors declare that they have no conflicts of interest or personal 
      relationships that might influence the work reported in this paper.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/21 06:00
PMCR- 2022/12/07
CRDT- 2022/12/19 04:00
PHST- 2022/07/11 00:00 [received]
PHST- 2022/10/12 00:00 [revised]
PHST- 2022/10/13 00:00 [accepted]
PHST- 2022/12/19 04:00 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/12/07 00:00 [pmc-release]
AID - 10.1155/2022/8360837 [doi]
PST - epublish
SO  - Can J Gastroenterol Hepatol. 2022 Dec 7;2022:8360837. doi: 10.1155/2022/8360837. 
      eCollection 2022.