PMID- 36532526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Undernutrition was a prevalent clinical problem among older adult patients with 
      heart failure in a hospital setting in Northwest Ethiopia.
PG  - 962497
LID - 10.3389/fnut.2022.962497 [doi]
LID - 962497
AB  - BACKGROUND: Undernutrition is a frequently noticed medical problem in patients 
      with heart failure. It is caused by poor nutrient intake, malabsorption, systemic 
      inflammation, neurohumoral activation, oxidative stress, and hypermetabolic 
      state. Undernutrition results in a decrease in the quality of life and the 
      survival rate in patients with heart failure. There is a paucity of documentation 
      on undernutrition among patients with heart failure in sub-Saharan African 
      countries. The study aimed to determine the magnitude and associated factors of 
      undernutrition among older adult patients with heart failure in the hospital 
      setting in Northwest Ethiopia. METHODS: An institutional-based cross-sectional 
      study was conducted at the University of Gondar Hospital, Northwest Ethiopia, 
      between 1 June 2021 and 31 October 2021. A consecutive sampling method was used 
      to recruit 262 study subjects. A Mini-nutritional assessment-full form (MNA-FL) 
      Questionnaire was used to extract nutritional information among patients with 
      heart failure. Patients with heart failure, who scored MNA-FL score <17, were 
      declared to have undernutrition. The data were entered into EPI Info version 
      4.6.0.0 and then exported to SPSS version 26 for analysis. Explanatory variables 
      associated with undernutrition in patients with heart failure were analyzed by 
      applying a logistic regression model. A P-value of <0.05 was used to declare a 
      significant association. RESULTS: A total of 262 patients with heart failure were 
      included in the study. The mean age (+/- SD) of the study subjects was 64.6 (+/- 9.2) 
      years. Hypertensive heart disease (111/262, 42%) was the most common cause of 
      heart failure. Hypertension was the frequently observed comorbid disease. Based 
      on the MNA-FL score for nutritional status, 75 out of 262 (28.6%, 95% CI: 
      22.9-34.4%) were undernourished (MNA-FL < 17), while 124 out of 262 (47.3%, CI: 
      41.5-53.1%) were at risk of undernutrition (MNA-FL = 17-23.5). The remaining 63 
      out of 262 (24.1%, 95% CI: 18.2-29.8%) study subjects were well nourished (MNA-FL 
      > 24). On a multivariate analysis, patients with severe heart failure (New York 
      Heart Association (NYHA) functional class III/IV) (AOR = 4.287, CI: 2.012-9.134, 
      P-value < 0.001), with a duration of illness of 3-5 years (AOR = 3.225, CI: 
      1.138-9.137, P-value = 0.028), with a duration of illness of >5 years (AOR = 
      4.349, CI: 1.592-11.879, P-value = 0.001), presence of comorbidities (AOR = 2.29, 
      CI: 1.06-4.96, P-value = 0.036), who underwent treatment with loop diuretics (AOR 
      = 2.983, CI: 1.407-6.326, P-value = 0.040), and who reside in a rural area (AOR = 
      5.119, CI: 2.481-10.560, P-value < 0.001) were at risk of developing 
      undernutrition. CONCLUSION: Undernutrition was a significant clinical problem in 
      older patients with heart failure. Nutritional interventions should be 
      prioritized for patients with chronic and severe heart failure.
CI  - Copyright (c) 2022 Ahmed, Tadesse, Alemu, Abebe and Tadesse.
FAU - Ahmed, Hussen
AU  - Ahmed H
AD  - Department of Internal Medicine, School of Medicine, College of Medicine and 
      Health Sciences, University of Gondar, Gondar, Ethiopia.
FAU - Tadesse, Abilo
AU  - Tadesse A
AD  - Department of Internal Medicine, School of Medicine, College of Medicine and 
      Health Sciences, University of Gondar, Gondar, Ethiopia.
FAU - Alemu, Hailemaryam
AU  - Alemu H
AD  - Department of Internal Medicine, School of Medicine, College of Medicine and 
      Health Sciences, University of Gondar, Gondar, Ethiopia.
FAU - Abebe, Alula
AU  - Abebe A
AD  - Department of Internal Medicine, School of Medicine, College of Medicine and 
      Health Sciences, University of Gondar, Gondar, Ethiopia.
FAU - Tadesse, Melaku
AU  - Tadesse M
AD  - Department of Internal Medicine, School of Medicine, College of Medicine and 
      Health Sciences, University of Gondar, Gondar, Ethiopia.
LA  - eng
PT  - Journal Article
DEP - 20221201
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9752898
OTO - NOTNLM
OT  - Ethiopia
OT  - MNA-FL score
OT  - University of Gondar
OT  - heart failure
OT  - undernutrition
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/01/01
CRDT- 2022/12/19 04:15
PHST- 2022/06/06 00:00 [received]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2022/12/19 04:15 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.962497 [doi]
PST - epublish
SO  - Front Nutr. 2022 Dec 1;9:962497. doi: 10.3389/fnut.2022.962497. eCollection 2022.