PMID- 36532701
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 1687-9627 (Print)
IS  - 1687-9635 (Electronic)
VI  - 2022
DP  - 2022
TI  - Basilar Predominant Emphysema: Thinking beyond Alpha-1-Antitrypsin Deficiency.
PG  - 9840085
LID - 10.1155/2022/9840085 [doi]
LID - 9840085
AB  - Basilar predominant emphysema, or disproportionate emphysematous involvement of 
      the lung bases compared to the apices, is an uncommon radiographic pattern of 
      emphysema traditionally associated with alpha-1-antitrypsin deficiency (AATD). We 
      present a case of a 59-year-old female with 41 pack-year tobacco use, Stage IV 
      COPD with supplemental oxygen, and bibasilar predominant emphysema who 
      successfully underwent bronchoscopic lung volume reduction. She presented with 
      recurrent hospitalizations for frequent exacerbations. After lung reduction, the 
      patient displayed improvement in functional status without hospitalizations at 
      the 15-month follow-up. Careful history taking is essential for any patients 
      diagnosed with lower lobe emphysema to elucidate the underlying etiology. This 
      case challenges the notion that basilar emphysema is sensitive or specific for 
      AATD and emphasizes that this pattern of emphysema has a broad differential 
      diagnosis and alternative etiologies should be considered. Our patient was 
      ultimately diagnosed with smoking-related emphysema, with atypical bibasilar 
      involvement. Furthermore, basilar predominant emphysema should be considered a 
      separate entity from its apical predominant counterpart.
CI  - Copyright (c) 2022 Ho-Man Yeung and Lauren Gaffaney.
FAU - Yeung, Ho-Man
AU  - Yeung HM
AUID- ORCID: 0000-0002-7188-9738
AD  - Department of Medicine, Lewis Katz School of Medicine, Temple University, 
      Philadelphia, PA, USA.
FAU - Gaffaney, Lauren
AU  - Gaffaney L
AD  - Department of Medicine, Lewis Katz School of Medicine, Temple University, 
      Philadelphia, PA, USA.
LA  - eng
PT  - Case Reports
DEP - 20221209
PL  - United States
TA  - Case Rep Med
JT  - Case reports in medicine
JID - 101512910
PMC - PMC9757930
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/12/09
CRDT- 2022/12/19 04:19
PHST- 2022/10/02 00:00 [received]
PHST- 2022/11/28 00:00 [revised]
PHST- 2022/11/30 00:00 [accepted]
PHST- 2022/12/19 04:19 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/12/09 00:00 [pmc-release]
AID - 10.1155/2022/9840085 [doi]
PST - epublish
SO  - Case Rep Med. 2022 Dec 9;2022:9840085. doi: 10.1155/2022/9840085. eCollection 
      2022.