PMID- 36532768
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 13
DP  - 2022
TI  - Targeting hypoxia-inducible factors for breast cancer therapy: A narrative 
      review.
PG  - 1064661
LID - 10.3389/fphar.2022.1064661 [doi]
LID - 1064661
AB  - Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low 
      cellular oxygen levels, are often overexpressed and activated in breast cancer. 
      HIFs modulate the primary transcriptional response of downstream pathways and 
      target genes in response to hypoxia, including glycolysis, angiogenesis and 
      metastasis. They can promote the development of breast cancer and are associated 
      with poor prognosis of breast cancer patients by regulating cancer processes 
      closely related to tumor invasion, metastasis and drug resistance. Thus, specific 
      targeting of HIFs may improve the efficiency of cancer therapy. In this review, 
      we summarize the advances in HIF-related molecular mechanisms and clinical and 
      preclinical studies of drugs targeting HIFs in breast cancer. Given the rapid 
      progression in this field and nanotechnology, drug delivery systems (DDSs) for 
      HIF targeting are increasingly being developed. Therefore, we highlight the HIF 
      related DDS, including liposomes, polymers, metal-based or carbon-based 
      nanoparticles.
CI  - Copyright (c) 2022 Luo, Jiang, Anfu Zheng, Zhao, Wu, Li, Du, Chen, Deng, Chen, Li, 
      Li, Gu, Sun, Xiao and Shen.
FAU - Luo, Shuang
AU  - Luo S
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
AD  - Department of Pharmacy, The Second People's Hospital of Jiangyou, Mianyang, 
      China.
FAU - Jiang, Yu
AU  - Jiang Y
AD  - Department of Pharmacy, The People's Hospital of Wusheng, Guang'an, China.
FAU - Anfu Zheng
AU  - Anfu Zheng
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Zhao, Yueshui
AU  - Zhao Y
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Wu, Xu
AU  - Wu X
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Li, Mingxing
AU  - Li M
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Du, Fukuan
AU  - Du F
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Deng, Shuai
AU  - Deng S
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Chen, Meijuan
AU  - Chen M
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Li, Wanping
AU  - Li W
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Li, Xiaobing
AU  - Li X
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Gu, Li
AU  - Gu L
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Sun, Yuhong
AU  - Sun Y
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
FAU - Xiao, Zhangang
AU  - Xiao Z
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - Department of Oncology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Shen, Jing
AU  - Shen J
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacology, School of 
      Pharmacy, Southwest Medical University, Luzhou, China.
AD  - Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou, China.
AD  - South Sichuan Institute of Translational Medicine, Luzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221201
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC9751339
OTO - NOTNLM
OT  - angiogenesis
OT  - breast cancer
OT  - drug delivery systems
OT  - glycolysis
OT  - hypoxia-inducible factors
OT  - tumor microenvironment
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/20 06:00
MHDA- 2022/12/20 06:01
PMCR- 2022/12/01
CRDT- 2022/12/19 04:21
PHST- 2022/10/08 00:00 [received]
PHST- 2022/11/18 00:00 [accepted]
PHST- 2022/12/19 04:21 [entrez]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/20 06:01 [medline]
PHST- 2022/12/01 00:00 [pmc-release]
AID - 1064661 [pii]
AID - 10.3389/fphar.2022.1064661 [doi]
PST - epublish
SO  - Front Pharmacol. 2022 Dec 1;13:1064661. doi: 10.3389/fphar.2022.1064661. 
      eCollection 2022.