PMID- 36534022
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20230313
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 42
IP  - 1
DP  - 2023 Feb
TI  - Real-world outcomes of Cook Zilver PTX in femoro-popliteal district from 
      multicenter experience.
PG  - 9-18
LID - 10.23736/S0392-9590.22.04959-8 [doi]
AB  - BACKGROUND: The purpose is to evaluate the follow-up outcomes after 
      femoro-popliteal stenting with Cook Zilver PTX in a multicenter experience. 
      METHODS: Collected data from four Units were retrospectively joined and analyzed 
      considering Zilver PTX deployed from August 2009 according to the instruction for 
      use. Patient demographics, preoperative comorbidities, Rutherford classification, 
      arterial characteristics and stent data were considered. Target lesion 
      revascularization (TLR) was defined as reintervention performed for >/=50% diameter 
      stenosis after recurrent clinical symptoms. Primary outcome was the freedom from 
      TLR (ffTLR) and its risk factors. Secondary outcomes were primary patency (PP) of 
      the stent, amputation-free survival (AFS) and their risk factors. RESULTS: 
      Considering 203 patients (mean age: 73.5 years +/-10.6; male: 66.5%) and 263 stents 
      (median 2 stents/patient, range 1-5stent/patient), chronic limb-threatening 
      ischemia (CLTI) affected 154 patients (75.9%). The length of the treated lesion 
      was <120 mm in 99 (48.8%), >/=120 mm and <200 mm in 65 (32%) and >/=200 mm in 39 
      (19.2%) cases, respectively; the reference vessel mean diameter was 5.5+/-0.7 mm; 
      chronic total occlusion was treated in 153 (75.4%) patients, the popliteal artery 
      was involved in 56 (27.6%) cases and prior endovascular intervention was 
      performed in 27 (13.3%) cases. Two or more crural run-off vessels were patent in 
      124 (61.1%). Mean follow-up was 23.2 months +/-21.3. At 1, 2 and 3 years, the ffTLR 
      was 90.6+/-4.2%, 86.4+/-6.1% and 80.4+/-8.3%, respectively, and the PP was 85.6+/-5.0%, 
      74.2+/-7.6% and 72.7+/-8.2%, respectively. Negative prognostic factor for ffTLR and 
      PP was the reference vessel diameter (P=0.001 and P<0.001, respectively). At 1, 2 
      and 3 years, the AFS was 81.8+/-6.0%, 75.5+/-7.1% and 74.2+/-7.5% respectively; 
      coronary artery disease (P=0.041) and CLTI (P=0.011) resulted negative prognostic 
      factors. CONCLUSIONS: In the real-world practice, around 3/4 of patients were 
      treated for CLTI. The rate of ffTLR is high, and PP is substantially lower. A 
      small vessel diameter (<5 mm) is a negative factor for both ffTLR and PP. The 
      rate of AFS is about 75% at 2 years and CLTI and coronary artery disease are 
      negative prognostic factors.
FAU - Bianchini Massoni, Claudio
AU  - Bianchini Massoni C
AD  - Unit of Vascular Surgery, Department of Medicine and Surgery, Azienda 
      Ospedaliero-Universitaria di Parma, Parma, Italy - claudiobianchinim@gmail.com.
FAU - Strozzi, Francesco
AU  - Strozzi F
AD  - Unit of Vascular Surgery, Department of General and Specialist Surgery, 
      Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
FAU - Epifani, Enrico
AU  - Epifani E
AD  - Unit of Radiology, Diagnostic Department, Azienda Ospedaliero-Universitaria di 
      Parma, Parma, Italy.
FAU - Zenunaj, Gladiol
AU  - Zenunaj G
AD  - Unit of Vascular Surgery, Department of Surgery, Azienda 
      Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
FAU - Ucci, Alessandro
AU  - Ucci A
AD  - Unit of Vascular Surgery, Department of Medicine and Surgery, Azienda 
      Ospedaliero-Universitaria di Parma, Parma, Italy.
FAU - Paladini, Ilaria
AU  - Paladini I
AD  - Unit of Radiology, Diagnostic Department, Azienda Ospedaliero-Universitaria di 
      Parma, Parma, Italy.
FAU - Gasbarro, Vincenzo
AU  - Gasbarro V
AD  - Unit of Vascular Surgery, Department of Surgery, Azienda 
      Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
FAU - Tusini, Nicola
AU  - Tusini N
AD  - Unit of Vascular Surgery, Department of General and Specialist Surgery, 
      Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
FAU - Freyrie, Antonio
AU  - Freyrie A
AD  - Unit of Vascular Surgery, Department of Medicine and Surgery, Azienda 
      Ospedaliero-Universitaria di Parma, Parma, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20221219
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - Paclitaxel/adverse effects
MH  - *Coronary Artery Disease
MH  - Retrospective Studies
MH  - *Peripheral Arterial Disease/surgery
MH  - *Drug-Eluting Stents
MH  - Femoral Artery/diagnostic imaging/surgery
MH  - Popliteal Artery/diagnostic imaging/surgery
MH  - Chronic Limb-Threatening Ischemia
MH  - Vascular Patency
MH  - Treatment Outcome
MH  - Prosthesis Design
EDAT- 2022/12/20 06:00
MHDA- 2023/03/14 06:00
CRDT- 2022/12/19 09:56
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
PHST- 2022/12/19 09:56 [entrez]
AID - S0392-9590.22.04959-8 [pii]
AID - 10.23736/S0392-9590.22.04959-8 [doi]
PST - ppublish
SO  - Int Angiol. 2023 Feb;42(1):9-18. doi: 10.23736/S0392-9590.22.04959-8. Epub 2022 
      Dec 19.