PMID- 36534127
OWN - NLM
STAT- MEDLINE
DCOM- 20230525
LR  - 20230525
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 75
IP  - 3
DP  - 2023 Jun
TI  - The immunogenetics of COVID-19.
PG  - 309-320
LID - 10.1007/s00251-022-01284-3 [doi]
AB  - The worldwide coronavirus disease 2019 pandemic was sparked by the severe acute 
      respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) that first surfaced in 
      December 2019 (COVID-19). The effects of COVID-19 differ substantially not just 
      between patients individually but also between populations with different 
      ancestries. In humans, the human leukocyte antigen (HLA) system coordinates 
      immune regulation. Since HLA molecules are a major component of 
      antigen-presenting pathway, they play an important role in determining 
      susceptibility to infectious disease. It is likely that differential 
      susceptibility to SARS-CoV-2 infection and/or disease course in COVID-19 in 
      different individuals could be influenced by the variations in the HLA genes 
      which are associated with various immune responses to SARS-CoV-2. A growing 
      number of studies have identified a connection between HLA variation and diverse 
      COVID-19 outcomes. Here, we review research investigating the impact of HLA on 
      individual responses to SARS-CoV-2 infection and/or progression, also discussing 
      the significance of MHC-related immunological patterns and its use in vaccine 
      design.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Srivastava, Anshika
AU  - Srivastava A
AD  - University of California San Francisco, San Francisco, CA, USA.
FAU - Hollenbach, Jill A
AU  - Hollenbach JA
AD  - University of California San Francisco, San Francisco, CA, USA. 
      Jill.Hollenbach@ucsf.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221219
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
EIN - Immunogenetics. 2023 Feb 23;:. PMID: 36820894
MH  - Humans
MH  - *COVID-19
MH  - SARS-CoV-2
MH  - Immunogenetics
MH  - Histocompatibility Antigens Class I/genetics
PMC - PMC9762652
OTO - NOTNLM
OT  - COVID-19
OT  - Disease susceptibility
OT  - Human leukocyte antigens
OT  - Polymorphism
EDAT- 2022/12/20 06:00
MHDA- 2023/05/25 06:42
PMCR- 2022/12/19
CRDT- 2022/12/19 11:12
PHST- 2022/10/07 00:00 [received]
PHST- 2022/11/19 00:00 [accepted]
PHST- 2023/05/25 06:42 [medline]
PHST- 2022/12/20 06:00 [pubmed]
PHST- 2022/12/19 11:12 [entrez]
PHST- 2022/12/19 00:00 [pmc-release]
AID - 10.1007/s00251-022-01284-3 [pii]
AID - 1284 [pii]
AID - 10.1007/s00251-022-01284-3 [doi]
PST - ppublish
SO  - Immunogenetics. 2023 Jun;75(3):309-320. doi: 10.1007/s00251-022-01284-3. Epub 
      2022 Dec 19.