PMID- 36535190 OWN - NLM STAT- MEDLINE DCOM- 20230123 LR - 20230208 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 171 DP - 2023 Jan TI - Associations between repeated measurements of urinary polycyclic aromatic hydrocarbon metabolites and thyroid hormones among reproductive-aged men. PG - 107698 LID - S0160-4120(22)00625-0 [pii] LID - 10.1016/j.envint.2022.107698 [doi] AB - BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been shown to disrupt thyroid function in toxicological studies, but epidemiological evidence is inconsistent. Furthermore, little is known on potential effects of mixtures of PAHs. OBJECTIVE: This study aimed to examine the associations of exposure to PAHs as individual chemicals and mixtures with thyroid hormones. METHODS: We included 378 men from a Reproductive Medicine Center in Wuhan, China. Ten monohydroxylated PAH (OH-PAH) metabolites in repeated urine specimens collected at two-time points and three thyroid hormones [thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3)] in one serum sample were measured. Multivariable linear regression models were applied to assess the associations between individual OH-PAH metabolites and thyroid hormones, and the associations with mixtures of OH-PAH metabolites were assessed by Bayesian kernel machine regression (BKMR) models. RESULTS: Multivariable linear regression models showed inverse associations between urinary 1-OHNa and TSH, between urinary 1-OHPh and 9-OHPh and FT3, as well as between urinary 2-OHPh, 3-OHPh, 9-OHPh and summation operatorOHPh and FT4, regardless of these individual OH-PAH metabolites modeled as continuous or tertile variables (e.g., -21.57 % in TSH; 95 % CI: -35.33 %, -4.88 % for the third vs first tertiles of 1-OHNa; p for trend = 0.014). BKMR models showed negative overall effects of all urinary OH-PAH metabolite mixtures on TSH, FT3, and FT4, and 1-OHNa, 9-OHPh, and 2-OHPh as the most important contributors, respectively, with linear inverse exposure-response associations when holding other OH-PAH metabolites at their median concentrations. CONCLUSION: Urinary OH-PAH metabolites as individual chemicals and mixtures were adversely associated with thyroid hormones among reproductive-aged men. CI - Copyright (c) 2022. Published by Elsevier Ltd. FAU - Zhou, Bin AU - Zhou B AD - Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Deng, Yanling AU - Deng Y AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Zeng, Qiang AU - Zeng Q AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Yang, Pan AU - Yang P AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Hu, Xijiang AU - Hu X AD - Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: 1936861339@qq.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221214 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - 0 (Thyroid Hormones) RN - 9002-71-5 (Thyrotropin) SB - IM MH - Male MH - Humans MH - Adult MH - *Polycyclic Aromatic Hydrocarbons/urine MH - Bayes Theorem MH - Thyroid Hormones MH - Reproduction MH - Thyrotropin OTO - NOTNLM OT - BKMR models OT - Co-exposure OT - Men OT - Polycyclic aromatic hydrocarbons OT - Thyroid hormones COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/12/20 06:00 MHDA- 2023/01/24 06:00 CRDT- 2022/12/19 18:22 PHST- 2022/03/23 00:00 [received] PHST- 2022/11/20 00:00 [revised] PHST- 2022/12/13 00:00 [accepted] PHST- 2022/12/20 06:00 [pubmed] PHST- 2023/01/24 06:00 [medline] PHST- 2022/12/19 18:22 [entrez] AID - S0160-4120(22)00625-0 [pii] AID - 10.1016/j.envint.2022.107698 [doi] PST - ppublish SO - Environ Int. 2023 Jan;171:107698. doi: 10.1016/j.envint.2022.107698. Epub 2022 Dec 14.