PMID- 36535498 OWN - NLM STAT- MEDLINE DCOM- 20230111 LR - 20230111 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 313 DP - 2023 Feb TI - Prenatal perfluoroalkyl substances exposure and neurodevelopment in toddlers: Findings from SMBCS. PG - 137587 LID - S0045-6535(22)04080-2 [pii] LID - 10.1016/j.chemosphere.2022.137587 [doi] AB - BACKGROUND: Prenatal perfluoroalkyl substances (PFAS) exposure has been reported to affect offspring neurodevelopment, while epidemiological evidences were limited and inconsistent. OBJECTIVES: We aimed to evaluate the associations between cord serum PFAS concentrations and neurodevelopment in toddlers from 1 to 3 years of age. METHODS: A total of 716 children from Sheyang Mini Birth Cohort Study (SMBCS) were included in this study. 12 PFAS concentrations were quantified in cord serum. Neurodevelopment was assessed using the Developmental Screen Test for Children Aged 0-6 Years at 1 year and the Gesell Developmental Schedules (GDS) at 2 and 3 years, respectively. Development quotient (DQ) z-score was standardized from DQ to eliminate the difference caused by two methods. We used generalized linear model (GLM) and Bayesian kernel machine regression (BKMR) to explore the associations of single or mixture PFAS exposure with neurodevelopment measurements at each time point. Associations between PFAS exposure and longitudinal changes in DQ z-score were investigated through generalized estimating equation (GEE) and trajectory analysis. RESULTS: In general, prenatal PFAS concentrations showed negative associations with neurodevelopment measurements at specific age. When accounting for longitudinal changes from 1 to 3 years of age, PFOA was negatively associated with DQ z-score (beta = -0.212, 95% CI: -0.422, -0.003), the association was only found significant in boys after stratified by gender (beta = -0.327, 95% CI: -0.616, -0.038). Meanwhile, increased PFBS (OR = 2.159, 95% CI: 1.177, 3.959) and PFHpA (OR = 1.700, 95% CI: 1.016, 2.846) exposure was associated with elevated odds for the low-score trajectory group. The results of mixture of PFAS further confirmed above findings. CONCLUSIONS: Our findings suggested that prenatal PFAS exposure may be associated with adverse neurodevelopment effects in the first 3 years of life. Further studies are warranted to confirm our findings. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Zhang, Boya AU - Zhang B AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Wang, Zheng AU - Wang Z AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Zhang, Jiming AU - Zhang J AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Dai, Yiming AU - Dai Y AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Feng, Chao AU - Feng C AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, No. 1380 West Zhongshan Road, Shanghai, 200336, China. FAU - Lin, Yuanjie AU - Lin Y AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, No. 1380 West Zhongshan Road, Shanghai, 200336, China. FAU - Zhang, Lei AU - Zhang L AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Guo, Jianqiu AU - Guo J AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Qi, Xiaojuan AU - Qi X AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China; Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Hangzhou, 310051, China. FAU - Chang, Xiuli AU - Chang X AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Lu, Dasheng AU - Lu D AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, No. 1380 West Zhongshan Road, Shanghai, 200336, China. FAU - Wu, Chunhua AU - Wu C AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: chwu@shmu.edu.cn. FAU - Zhou, Zhijun AU - Zhou Z AD - School of Public Health/MOE Key Laboratory of Public Health Safety/ NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: zjzhou@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20221216 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Male MH - Pregnancy MH - Female MH - Humans MH - Child, Preschool MH - Infant MH - Cohort Studies MH - *Environmental Pollutants/toxicity MH - Bayes Theorem MH - *Prenatal Exposure Delayed Effects/chemically induced MH - *Fluorocarbons/toxicity MH - *Alkanesulfonic Acids OTO - NOTNLM OT - Bayesian kernel machine regression OT - Longitudinal study OT - Neurodevelopment OT - Perfluoroalkyl substances OT - Toddler OT - Umbilical cord blood COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/12/20 06:00 MHDA- 2023/01/12 06:00 CRDT- 2022/12/19 19:25 PHST- 2022/08/07 00:00 [received] PHST- 2022/12/13 00:00 [revised] PHST- 2022/12/15 00:00 [accepted] PHST- 2022/12/20 06:00 [pubmed] PHST- 2023/01/12 06:00 [medline] PHST- 2022/12/19 19:25 [entrez] AID - S0045-6535(22)04080-2 [pii] AID - 10.1016/j.chemosphere.2022.137587 [doi] PST - ppublish SO - Chemosphere. 2023 Feb;313:137587. doi: 10.1016/j.chemosphere.2022.137587. Epub 2022 Dec 16.