PMID- 36535499 OWN - NLM STAT- MEDLINE DCOM- 20230111 LR - 20230111 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 313 DP - 2023 Feb TI - Assessment of the per- and polyfluoroalkyl substances analysis under the Stockholm Convention - 2018/2019. PG - 137549 LID - S0045-6535(22)04042-5 [pii] LID - 10.1016/j.chemosphere.2022.137549 [doi] AB - The comparability of laboratories for the analysis of per- and polyfluoroalkyl substances (PFAS) was assessed in the fourth round (2018/2019) of a series of interlaboratory assessments coordinated by the United Nations Environment Programme (UNEP) in support of the Stockholm Convention quality assurance activities as to persistent organic pollutants (POPs) laboratories reporting data under this Convention. The participating laboratories were asked to analyse PFAS concentrations in a test solution of the target compounds, in the four core matrices of the global monitoring plan (GMP), human milk, human plasma, an air extract, and water, and in a sediment and a fish matrix. 39 participating laboratories submitted PFAS data for one or more test materials. The majority of the participating laboratories originated from the Asia-Pacific region, and from the 'Western European and other groups' (WEOG). Only one laboratory from the group 'Latin America and Caribbean' (GRULAC), and two from the Central and Eastern Europe (CEE) region submitted results. None of the African laboratories submitted data. The coefficients of variation (CVs) varied from 7% to 24% (mean 14%) for the test solution. Mean CVs for all matrices, except for the human plasma test material (18%), were above the satisfactory limit of 25%. The highest mean CV was found for human milk (61%). In total 1457 z-scores were assigned of which 64% were satisfactory (|z| < 2). Instrumentation used was mainly high-performance liquid chromatography (HPLC), in combination with various mass spectrometric (MS) techniques, in most cases tandem MS (MS/MS). Additional PFAS beyond perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), which are listed at the Stockholm Convention POPs list, as well as water as a matrix for PFAS only and human plasma were added as a service for the laboratories. CI - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - van der Veen, Ike AU - van der Veen I AD - Vrije Universiteit, Environment & Health, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands. Electronic address: ike.vander.veen@vu.nl. FAU - Fiedler, Heidelore AU - Fiedler H AD - Orebro University, School of Science and Technology, MTM Research Centre, SE-701 82, Orebro, Sweden. FAU - de Boer, Jacob AU - de Boer J AD - Vrije Universiteit, Environment & Health, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands. LA - eng PT - Journal Article DEP - 20221216 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 059QF0KO0R (Water) SB - IM MH - Animals MH - Female MH - Humans MH - Tandem Mass Spectrometry MH - *Environmental Pollutants/analysis MH - Fishes MH - *Fluorocarbons/analysis MH - Water OTO - NOTNLM OT - Interlaboratory assessment OT - Perfluorinated alkyl substance OT - Plasma OT - United Nations OT - Variation OT - Water COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/12/20 06:00 MHDA- 2023/01/12 06:00 CRDT- 2022/12/19 19:25 PHST- 2022/07/15 00:00 [received] PHST- 2022/12/01 00:00 [revised] PHST- 2022/12/11 00:00 [accepted] PHST- 2022/12/20 06:00 [pubmed] PHST- 2023/01/12 06:00 [medline] PHST- 2022/12/19 19:25 [entrez] AID - S0045-6535(22)04042-5 [pii] AID - 10.1016/j.chemosphere.2022.137549 [doi] PST - ppublish SO - Chemosphere. 2023 Feb;313:137549. doi: 10.1016/j.chemosphere.2022.137549. Epub 2022 Dec 16.